Background: Fine Needle Aspiration Cytology (FNAC) is important for pre-operative diagnosis of benign and malignant thyroid lesions. It is usually the first line of investigation and a minimally invasive diagnostic procedure whose essential role is to diagnose and distinguish benign from malignant lesions. Thus the present study was undertaken to determine sensitivity, specificity and accuracy of FNAC in the diagnosis of thyroid lesions and to correlate cytological findings with histopathology. Methods:A prospective study was conducted in a tertiary care centre to study FNAC of thyroid lesions along with its histopathological correlation over a period of 2 years starting from June 2013 to June 2015Result: 56(93%) patients were females and 4(7%) patients were males. Patients age ranged from 15 to 65 years .Commonest lesion encountered in thyroid gland was colloid goitre, while papillary carcinoma was the most frequent malignant lesion. Cyto-histopathological correlation of 60 cases was done. Sensitivity ,specificity and diagnostic accuracy of the study for malignant lesions was 96.36%,100%,and 96.66% respectively. Conclusion:FNAC is a safe, simple, highly accurate, economical method for evaluation of palpable thyroid lesions. There is almost perfect cyto-histopathological concordance and the results are consistent with those available in the literature. FNAC helps in avoiding unnecessary surgeries in patients diagnosed to have a benign pathology based on cytology. Thus FNAC serves as a useful screening test to triage thyroid lesions before surgery.

Introduction: With urbanization and increase in sedentary lifestyle, prevalence of CAD (Coronary artery disease) is looming large as the new epidemic afflicting Indians. Altered platelet morphology and functions have been linked with the formation and propagation of thrombotic event. Platelet indices (Mean platelet volume -MPV, Platelet distribution width -PDW, Platelet large cell ratio -PLCR) are determinants of platelet functionality. Aims and Objectives: 1. To study platelet indices (MPV, PDW, P-LCR) in CAD; 2. To compare platelet indices in patients with myocardial infarction, stable CAD and control population. Material and Methods: A comparative and prospective study was conducted on 100 patients each of MI & stable CAD on antiplatelet therapy and 100 age and sex matched healthy individuals as controls. Platelet indices were measured using an Automated Blood Counter SYSMEX XN-1000. Troponin T and CK-MB levels were collected from clinical data in MI cases. Results: Platelet indices were significantly higher in MI patients in comparison to stable CAD and control groups. Stable CAD patients also showed significantly higher platelet indices in comparison to control groups. (p value <0.001) Conclusion: The present study showed a significantly higher MPV, PDW and P-LCR in CAD patients in comparison to control group. Among CAD patients, MI patients had significantly higher platelet indices than stable CAD patients. Hence platelet indices can be used as simple and cost effective predictive parameters to predict CAD. Their use in a risk stratification system to predict MI and in response to intervention are worthy of consideration.

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