5 At doses up to 1000 pg kg-', i.v., RS 25259-197 produced no meaningful haemodynamic changes in anaesthetized dogs. 6 In summary, RS 25259-197 is a novel, highly potent and orally active 5-HT3 receptor antagonist in vivo. With respect to its anti-emetic activity, RS 25259-197 appears to be a significant improvement over ondansetron in terms of potency and duration of action.
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