No abstract

Neutron brachytherapy alone was an effective and safe treatment for early stage esophageal squamous cell cancer.

New technique is trending in spatially fractionated radiotherapy with protons to utilize the spot scanning together with a physical collimator to obtain minibeams. The primary goal of this study is to quantify ambient neutron dose equivalent (${H}^{\ast }(10)$) due to the secondary neutrons when physical collimator is used to achieve desired minibeams. The ${H}^{\ast }(10)$ per treatment proton dose (D) was assessed using Monte Carlo code TOPAS and measured using WENDI-II detector at different angles (135, 180, 225 and 270 degrees) and distances (11 cm, 58 and 105 cm) from the phantom for two cases: with and without physical collimation. Without collimation $\frac{H^{\ast }(10)}{D}$ varied from 0.0013 to 0.242 mSv/Gy. With collimation $\frac{H^{\ast }(10)}{D}$ varied from 0.017 to 3.23 mSv/Gy. Results show that the secondary neutron dose will increase tenfold when the physical collimator is used. Regardless, it will be low and comparable to the neutron dose produced by conventional passive-scattered proton beams.

A novel tissue-equivalent proportional counter (TEPC) based on a gas electron multiplier (GEM) for measuring H*(10) for neutrons was designed and constructed. The pulse height spectra (PHS) of two different neutron sources (a 252Cf source and a AmBe source) were measured using the new TEPC. The measurements were made with the TEPC filled with two different gases (10P gas and a propane-based tissue-equivalent gas) at various pressures. A computer simulation of the new TEPC, based on the Monte Carlo method, was performed to obtain the PHS for the two neutron sources. It is shown that the experimental results agree well with the simulation results for both 252Cf and AmBe neutron sources. Several outstanding problems are discussed and suggestions are made to make the GEM-based TEPC a practical neutron rem meter. The potential advantage of this novel neutron rem meter would be its low weight and compactness.