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Background: Polycystic Ovarian Syndrome is one of the most common metabolic and reproductive disorder among women of reproductive age. This condition is characterized by elevated androgen levels, anovulatory menstrual abnormalities and multiple small cysts in ovaries. This female endocrine disorder is prevalent in age group of 18-45 years with rate ranging from 2.2% to 26%. Sedentary life style, faulty dietary habits lead to obesity in young adults which results in metabolic and hormonal disturbances such as insulin resistance, hyperandrogenemia etc. In Ayurvedic literature, the features associated with PCOS closely resemble with Nasta Artava, Ksheen Artava and a group of Yoni Vyapada like Bandhya, Arajska, Lohitkshara and Artava Vaha Strotas Viddh Lakshana mentioned by Acharya Sushruta. PCOS also has close resemblance with Pushpghani Jatharini mentioned by Acharya Kashyapa. Symptoms of PCOS mimic with conditions like Sthoulya, Aratava Kshaya, Agni Mandya, Rrakta/Medo Dhatu Dushti, Granthi Roga. So, based upon Rog lakshana and dosha dushya involvement, Ayurveda explains Nidana parivarjanam and Shamshodhan as a prime line of treatment for PCOS. Aim & Objectives: The main aim of this study is to establish the role of Samshodhan therapy in PCOS. PCOS can be considered as Tridoshaj Vyadhi with Vata & Kapha predominance that is the reason Vamana for Kapha Shodhan and Virechana for Vata and Pitta Sanshuddhi were planned to achieve desired results. Results: In this case study, a 27 years female patient suffering from symptoms like Ksheen Artava, Granthibhoot artava, Sthoulya, was managed with Samshodhan therapy and got complete relief from symptoms. Conclusion: This case study corroborates the importance of Samshodhan Chikitsa in PCOS.