SummaryThis study aims to investigate the impact of gestational diabetes mellitus (GDM) on the long-term risks of diabetes in women with prior GDM, including the effect at different time periods after GDM. We searched PubMed and other databases to retrieve articles which were published prior to February 28, 2017. Cohort studies which evaluated the risk and time of onset of diabetes postpartum in women with and without GDM were included. Meta-analysis with random effects models was used to obtain pooled relative risks and 95% confidence intervals for the risk of diabetes. Subgroup analyses were performed to check for different effect sizes as well as consistency across groups. Multivariable logistic regression was used to adjust for confounders. Thirty cohort studies with 2,626,905 pregnant women were included. Women with prior GDM had 7.76-fold (95% confidence intervals: 5.10-11.81) unadjusted pooled risk of diabetes as compared with women without GDM, whilst the adjusted risk was 17. 92-fold (16.96-18.94). The adjusted ORs of GDM for diabetes among women at <3, ≥3 -<6 and ≥6 -<10 years after GDM were 5.37 (3.51-9.34), 16.55 (16.08-17.04) and 8.20 (4.53-14.86), respectively. Women with prior GDM had substantially increased risk of diabetes, with the risk highest during the 3-6 years after GDM.

Liraglutide can enhance insulin-induced GLUT4 translocation by inhibiting IRS1 serine phosphorylation in PA-treated muscle cells.

This study reveals a positive correlation between frequency of chili consumption and muscle strength in adult males. Further studies are necessary in order to determine whether there is a causal relationship between chili consumption frequency and muscle strength.

The shield construction is a mature tunnel construction technology. Grouting behind segment wall synchronously during shield construction is an important measure to control stratum deformation, reduce ground settlement and prevent tunnel water seepage. The quality of grouting can significantly affect the quality of tunnel construction. The method of grouting quality judgment in early tunnel construction is inefficient and uncertain. To ensure the safety of tunnel structure, it is an urgent technical innovation to study the non-destructive testing technology for grouting effect of shield segment wall. Nowadays, the general Non-destructive testing methods include ground penetrating radar detection and seismic wave detection. These two methods can meet most of the needs of grouting defect detection behind the wall, but also have their own advantages and disadvantages. Therefore, this study proposes the combination of ground penetrating radar and seismic wave method of shield tunnel wall after grouting defects Non-destructive detection method, first, ground penetrating radar is used for scanning probe shield wall after grouting, and then according to the seismic wave method is used to further verify the results for some suspected injury, while ensure the detection efficiency to improve recognition accuracy. Finally, the defect detection and verification of the proposed method was carried out based on the shield segment model test platform, and this proposed method was successfully applied to the actual project of a metro line in Foshan.