BackgroundPsoriasis is an immune‐mediated, chronic inflammatory disease with diverse phenotypes. However, its biological diversity has not been well‐characterized in Chinese psoriasis population.ObjectivesTo characterize psoriasis biological heterogenicity using gene expression profiles of lesional skin biopsy specimens in a Chinese psoriasis population.MethodsLesional tissues and blood samples from Chinese psoriasis patients (n = 40), atopic dermatitis (AD) patients (n = 25) and age‐matched healthy controls (n = 19) were investigated by using real‐time PCR array, histological evaluation and flow cytometry. Unsupervised hierarchical clustering was performed using gene expression profiles of patients with psoriasis.ResultsTwo distinct psoriasis clusters were identified. Both clusters indicated high TH17 activation. One cluster (n = 6 of 40 consecutive psoriasis patients) indicated a strong TH2 component in skin lesions, with early onset and low peripheral blood eosinophil level. Significantly higher IL‐4, IL‐13, IL‐25, IL‐31 and TSLP gene induction typified this cluster of psoriasis patients, even compared with AD patients. Both psoriasis clusters were characterized by neutrophilic microabscess formation. Histologically, the TH2 high psoriasis cluster indicated a low percentage of perivascular eosinophils.ConclusionsTwo distinct psoriasis clusters were identified. One presented early onset and a low eosinophil level, indicating TH17 polarization and a strong TH2 component. These results laid the foundation for further demonstrating the pathogenesis of psoriasis in Chinese population.