This study demonstrated that maintenance of blood glucose in a liberal range after coronary artery bypass grafting led to similar outcomes compared with a strict target range and was superior in glucose control and target range management. On the basis of the results of this study, a target blood glucose range of 121 to 180 mg/dL is recommended for patients after coronary artery bypass grafting as advocated by the Society of Thoracic Surgeons.

Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting approximately 2.2 million Americans. Because several studies have suggested that changes in mitochondrial function and morphology may contribute to AF, we developed a novel proteomic workflow focused on the identification of differentially expressed mitochondrial proteins in AF patients. Right human atrial tissue was collected from 20 patients, 10 with and 10 without AF, and the tissue was subjected to hydrostatic pressure cycling-based lysis followed by label-free mass spectrometric (MS) analysis of mitochondrial enriched isolates. Approximately 5% of the 700 proteins identified by MS analysis were differentially expressed between the AF and non-AF samples. We chose four differentially abundant proteins for further verification using reverse phase protein microarray analysis based on their known importance in energy production and regulatory association with atrial ion channels: four and a half LIM, destrin, heat shock protein 2, and chaperonin-containing TCP1. These initial study results provide evidence that a workflow to identify AF-related proteins that combines a powerful upfront tissue cell lysis with high resolution MS for discovery and protein array technology for verification may be an effective strategy for discovering candidate markers in highly fibrous tissue samples.

Background The professional Burnout Syndrome (BOS) or Burnout is considered a professional disease made up of three interrelated dimensions (emotional exhaustion, depersonalization and lack of personal fulfillment). BOS has been documented to most severely affect the healthcare professions, especially dentists. On the other hand, its appearance has been documented at an early age, during dental training. However, there are no studies that analyze its incidence in professionals dedicated to Oral Surgery and Implantology, determining the age of onset and related factors. Material and Methods The modified Maslach questionnaire was carried out anonymously among the professors and students of the Master of Oral Surgery and Implantology at the Complutense University of Madrid. A total of 36 participants were enrolled in this study and the results of the modified Maslach Questionnaire were established into four groups [1st year (n=6), 2nd year (n=6), 3rd year (n=6) postgraduate students and clinical teachers (n=18)]. The following variables were recorded: Age, sex, years of experience, weekly hours of work, dedication on weekends and scope of work. The statistical analysis performed included Pearson's correlation, analysis of variance, Student's t-test, F-Anova, Chi-Square and Gamma correlation. Statistical Significance of the tests was established of p≤0.05. Results 36 questionnaires were analyzed, of which 22.2% (n = 8) presented BOS, and 77.8% (n = 28) a medium risk of suffering it. The mean values and standard deviation ​​of emotional exhaustion (7.50 ± 2.43; 9.83 ± 4.12; 15.83 ± 6.21; 30.22 ± 7.86), depersonalization (5.50 ± 1.23; 50 ± 3.27; 11.33 ± 1.75; 17.56 ± 4.13), low personal fulfillment (39.67 ± 3.72; 39.33 ± 2.34; 43.17 ± 3, 55; 37.33 ± 5.51) and professional burnout (54.33 ± 2.66; 61.67 ± 2.88; 70.33 ± 5.43; 85.11 ± 9.05) in the four groups respectively. A significant association was found in the appearance of emotional exhaustion and depersonalization, years of experience, weekly work hours and the work environment. Conclusions BOS is a disease that can appear from 30 years of age, after 5 years of professional experience and when there is a clinical consultation of 40 hours a week. Oral Surgery and Implantology seems to be a risk activity for the manifestation of depersonalization. Key words: Burnout syndrome, oral surgery, dental implants, students, clinical teachers, dental education.

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Background: Reports of successful cardiac surgical outcomes have focused on mortality and morbidity. However, health related quality of life (HRQL) is now being recognized as an important outcome measure. The objective of this study was to assess the impact of in-hospital postoperative complications on physical and mental HRQL in cardiac surgery patients from baseline to 6 and 12 months after surgery. Methods: Patients who underwent cardiac surgery since September 2005 were included (n=702). All patients completed the Short Form Health Survey (SF-12) prior to surgery, and at 6 and 12 months after surgery. Norm-based physical and mental components of HRQL were calculated, with higher scores indicating better HRQL. In-hospital postoperative complications were defined using the Society of Thoracic Surgeons guidelines. Results: Group 1 (n=533) had no in-hospital postoperative complications and Group 2 (n=169) experienced complications. The groups did not differ at baseline on physical or mental HRQL. There were significant main effects of time (F=32.9, p<0.001) and group (F=14.9, p<0.001) for physical HRQL, which showed an increase in scores over time and higher scores in Group 1. The significant interaction of time by group (F=6.6, p<0.02) indicated that physical HRQL increased more in Group 1 from baseline to 6 months and more in Group 2 from 6 to 12 months. The main effect of time was significant for mental HRQL (F=4.7, p<0.04), which showed an increase from baseline to 6 months and a slight decrease between 6 and 12 months. The interaction of time by group was not significant for mental HRQL. It is interesting to note, however, that the groups increased similarly from baseline to 6 months, but Group 1 showed a decline from 6 to 12 months and Group 2 continued to show an increase in mental HRQL from 6 to 12 months. Conclusion: In-hospital postoperative complications significantly affect improvements in HRQL. Patients that did not experience postoperative complications had a significantly better and faster improvement in physical HRQL from baseline to 1 year. Despite these differences in physical HRQL, the two groups increased similarly on mental HRQL. Further study is needed to explore this finding with a larger sample and longer follow-up time points after surgery.