Karanganyar Regency is one of the districts in Central Java which prone of the natural disasters. Based on data Posdes 2018, it is known that the types of disasters that often occurred in Karanganyar Regency during the last three years, from 2015 to 2017 were landslides, floods, and drought. Therefore, it is important to know the multi-risk level of the three types of disasters. The method used in this research is scoring and weighting, as well as overlay between constituent parameters. Based on the results of research using the VCA matrix multiplication method, it is known that the high risk level covers 3,589.67 Ha or 4.46% areas that spread in 15 districts (except Jatipuro and Jumapolo); moderate risk level covers 34,624.94 Ha or 43.04% areas that spread in 16 districts (except Tasikmadu); The low risk level covers 42,254.98 Ha or 52.53% areas that spread in 7 districts (Colomadu, Gondangrejo, Tasikmadu, Matesih, Tawangmangu, Jumapolo, Jatiyoso).