Non-adherence to good manufacturing practice alongside improper handling during dispensing, packaging and inadequate post-marketing surveillance of pharmaceutical products accounts to product’s deterioration reduced therapeutic effect and adversely affects patient’s safety especially the paediatrics. This study evaluates the microbiological quality of various brands of paediatric cough syrups marketed and used within Port Harcourt metropolis. Twenty cough syrup brands were experimented on in duplicate, coded as USS and UNS (used and unused respectively). They were subjected to organoleptic assessment, pH, viscosity, total aerobic viable count, as well as resistance- susceptibility test of isolates using standard conventional techniques. Results showed viscosity value of 0.22 - 9.09 Pascal seconds (Pa.s), pH values of 3.13 - 8.34 across the UNS and USS categories respectively. While 80% of the UNS cough syrup samples were free from potential microbial threat, 20% fraction and all USS cough syrup (100%) samples were contaminated with objectionable microorganisms and non- compliant with USP permissible limit. The potentially pathogenic isolates were Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumonia, demonstrating varied resistance pattern to exposed antibiotic categories. Microbial contamination might have been caused by poor quality control and improper handling of the products during use. This calls for more stringent measures during product manufacturing and handling to ensure patient’s safety and forestall possible transference of resistance strain.

BACKGROUND: High body mass index (obesity) is a great health threat to aging individuals which results in increased blood pressure. MATERIALS AND METHODS: The Study was carried out in four different communities namely: Ikom, Akamkpa, Calabar South and Calabar Municipal of Cross River State, Nigeria.  It was carried out amongst 130 women who voluntarily gave their consent during a cervical screening done in their various locations during the period of December 2016 to January 2017 in Cross River State, Nigeria. Blood pressure was measured using a standard mercury sphygmomanometer to obtain both the diastolic and systolic blood pressure of the various individuals. The height and weight were obtained using a weighing balance and a stadiometer respectively to get the weight and height. It was summarized age group wise and cut off points gotten from the individuals and reviewed using the WHO classification of body mass index classification. Data obtained were presented using frequencies and percentages. RESULTS: Underweight individuals (8)had a total percentage of 6.15%.A total of  46(35.40%) of the individuals were of normal weight..46 and 30 of the individuals had a percentage of 35.40% and 23.08%respectively(overweight and obese).A maximum number of the individuals were normal(were neither prehypertensive nor hypertensive). 49 and 19 individuals were prehypertensive in systolic and diastolic blood pressure respectively and 7 and 16 were hypertensive in systolic and diastolic blood pressure respectively. CONCLUSION: A high body mass index and hypertension correlate with advancing age. and can be prevented by living an acceptable lifestyle devoid of it Triggers like alcohol, smoking ,reduced salt intake etc and having a regular routine check-up done periodically.