Sulfathiazole (SFTZ) is an antibacterial drug that contains the organosulfur compounds. It is used as a short-acting sulfa drug. The metal complexes of sulfa-drug have gained considerable importance due to their pronounced biological activity. The sulfa-drugs have received great attention because of their therapeutic applications against bacterial infections. Mn(II) complex of sulfathiazole was synthesized by the reaction of sulfathiazole with MnCl2.4H2O. The Mn (II) complex was characterized based on UV, IR, 1H NMR Spectroscopy and x-ray powder diffraction. The electronic spectrum of the ligand showed intra charge transfer which was assigned to the chromophores present in the ligand, while that of the complex suggested intra ligand charge transfer (ILCT) and ligand to metal charge transfer (LMCT). In the IR spectrum of sulfathiazole, the N-H stretch of SO2NH appeared at 3255.23 cm-1. In the IR spectrum of the metal complex, this band was absent. This suggested the deprotonation of the N-H of SO2NH during the complexation reaction. This showed that sulfathiazole acted as a monodentate ligand. 1H NMR spectrum of [Mn(SFTZ)] complex showed the involvement of the nitrogen atom of SO2NH. The crystal structure of [Mn(SFTZ)] complex belongs to monoclinic system, space group P1, with cell parameters of a= 4.519Å, b = 8.704Å, c = 12.608Å, V = 493.5Å3, β = 95.69º. Molecular docking suggested that the ligand/complex bonded effectively with the E.coli and S.aureus because their global binding energies were negative. The binding interactions of ligand/complex with E. coli and S. aureus were predicted. Molecular docking predicted the feasibility of the biochemical reactions before experimental investigation. It was concluded that sulfathiazole behaved as a monodentate ligand towards Mn (II) ion. The binding energy and interaction of [Mn(SFTZ)] with E.coli and S. aureus have also shown that inhibition of the bacterial species is feasible. The mechanism of action of [Mn(SFTZ)] with E. coli and S. aureus is now well understood.

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Aims: An investigation of characteristic long term air pollutants known for temporal and spatial behaviors was conducted due to increased pollution scenarios in Nigerian cities as a result of deprived environmental enforcement of statutory obligations. Study Design: One of the worlds’ most polluted cities (Onitsha lower basin) in Nigeria was selected for spatio-temporal study of three criteria pollutants combined with GIS and MATLAB alongside associated meteorological conditions during harmattan. Methodology: 72-hourly analyses of the nine different locations having 4 sampling sites and 500 meters apart were done from December to February which generated over 19, 440 experimental data per quarter of each annual study. Results: Upper Iweka/Nitel area recorded the highest concentration of SO2 pollutant at (94.2 µg/m3) due to longer residence times and low wind mixing height. Borromeo hospital showed the least active NO2 region but converges at points 1 due to North-east wind dissimilar to sampling points 1 having the lowest PM10 distribution. Measured temperature parameter correlates inversely with relative humidity and precipitation. The GIS spatial representation corresponded to temporal variability of gaseous and particulate pollutants. Conclusion: All sampled areas had AQI above 50; hence the study identified SO2, NO2, and PM10 as Primary pollutants of Onitsha lower basin.

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