Lower level of apolipoprotein A1 in urine is suggestive of SRNS. Alpha 2 macroglobulin, retinol binding protein 4 and orosomucoid 2 are markers associated with FSGS, with alpha 2 macroglobulin being most predictive.
Subclinical non-autoimmune hypothyroidism is present in a significant proportion of children with SRNS despite partial or complete remission. Thyroid profile should be evaluated routinely in this subset of patients.
DESCRIPTIONPneumothorax, pneumomediastinum (PM) and subcutaneous emphysema (SE) due to foreign body aspiration (FBA) are rarely reported in clinical practice.1 2 We present here a 3-year-old boy who posed a diagnostic dilemma to us at presentation with SE following a subacute history of respiratory tract infection of 2 weeks duration. The child had been treated with oral antibiotics for 7 days prior to presentation, but the symptoms did not resolve and seemed to only worsen with time. Therefore, a possibility of FBA was strongly considered on the basis of his clinical picture and radiological investigations suggesting hyperinflation and collapse at different places with air leaks (figures 1 and 2). The CT scan of the chest also revealed epidural air extending from C5 to T12 vertebral level suggestive of external pneumorrhachis (figure 3). Accordingly, a diagnostic bronchoscopy was performed which revealed a peanut in the left main bronchus, which was successfully extracted leading to resolution of symptoms in the child. Although documented earlier, PM and SE secondary to FBA are very rare events. The association of FBA with pneumorrhachis is rarer still, with only one documented case of the same till date. 3 We chose to report this case to highlight the diagnostic challenge the child had posed to us at presentation, which could only be confirmed due to a high index of suspicion. We also wish to highlight the rare association of pneumorrhachis with FBA as was seen in this child.
Learning points▸ A possibility of foreign body aspiration should be considered in any child <5 years of age presenting with extra-alveolar air. ▸ Timely performed bronchoscopy may be lifesaving and lung saving in these children. ▸ Parents should be educated about the selection of food and toy materials in young children to avoid such unintentional injuries.
The original version of this article unfortunately contained errors. In the ''Methods'' section of the main text, under the heading ''Participants'', the sentences that begin with ''Remission'' and ''No response'' should read: Remission was defined as complete (Up/Uc \0.2 mg/ mg) or partial (Up/Uc between 0.2 and 2 mg/mg, serum albumin [2.5 g/dL, and no edema). No response was the presence of nephrotic range proteinuria (Up/Uc [2 mg/ mg), serum albumin \2.5 g/dL, or edema. In Table 2, in the first column, for the line ''Spot Up/ Uc'', the unit should be ''mg/mg''. In Table 3, in the first column, for the line ''Total duration of illness (years)'', the value of SRNS without subclinical hypothyroidism, and the unit for the line ''Cumulative dose of prednisolone'' were shown incorrectly. The corrected tables are as follows: The online version of the original article can be found under
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