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Background: Fatigue due to iron deficiency anaemia (IDA) has not been regularly evaluated in clinical studies. The aim of this study is to assess patient reported outcomes amongst individuals diagnosed with IDA before and after receiving intravenous ferric carboxymaltose. Fatigue and satisfaction will be measured using the validated Functional Assessment of Chronic Illness Therapy – Fatigue (FACIT-fatigue) scale and the validated Nordic Patient Experiences Questionnaire (NORPEQ), respectively.Methods: Thirty eligible patients receiving IV ferric carboxymaltose at the Royal Brisbane and Women’s Hospital were enrolled to participate in interviews; two patients were lost to follow up. Mean change in FACIT-fatigue score from the baseline day of IV ferric carboxymaltose treatment to week 4 post treatment was measured. Patient satisfaction with the overall process of treatment was measured on the day of treatments. Approval for Ethics exemption was obtained by the RBWH ethics committee.Results: A one-way ANOVA was conducted to compare the patient questionnaire results at baseline on the day of receiving the IV ferric carboxymaltose and after a four week follow up via telephone interview. There was a significant effect of improvement of FACIT-fatigue scores on follow up at the p<.05 level [F(1,54), = 7.60, p = .008]. Patient satisfaction was assessed by analysing NORPEQ, an 8-item questionnaire. Patients had reported overall higher satisfaction scores at baseline and follow-up, averaging 91% and 94%, respectively and were not significant in treatment at the p<.05 level [F(1,52), = 1.37, p = .246].Conclusions: The use of validated patient reported outcome measures and experiences provides valuable insights into the patients’ perspective. Physiological and biochemical data outcomes are often used as the gold-standard of medical research. However, patient experience and self-perceived physiological improvement are imperative when measuring the success of a medical intervention and the benefits it provides to patients and consumers. Further research is needed to combine the subjective patient experience data with objective physical, biochemical, or physiological data. Combined, they can provide a thorough and comprehensive assessment of an intervention. Furthermore, a comparison of outcomes administering IV iron or oral iron therapy would provide valuable information about efficacy.Trial registration: Not registered