Introduction:Parenteral nutrition (PN) in childhood is a treatment whose characteristics are highly variable depending on the age and pathology of the patient. Material and methods: The Standardization and Protocols Group of the Spanish Society for Parenteral and Enteral Nutrition (SENPE) is an interdisciplinary group formed by members of the SENPE, the Spanish Society of Gastroenterology, Hepatology and Pediatric Nutrition (SEGHNP) and the Spanish Society of Hospital Pharmacy (SEFH) that intends to update this issue. For this, a detailed review of the literature has been carried out, looking for the evidences that allow us to elaborate a Clinical Practice Guide following the criteria of the Oxford Center for Evidence-Based Medicine. Results: This manuscript summarizes the recommendations regarding indications, access routes, requirements, modifi cations in special situations, components of the mixtures, prescription and standardization, preparation, administration, monitoring, complications and home NP. The complete document is published as a monographic number. Conclusions: This guide is intended to support the prescription of pediatric PN. It provides the basis for rational decisions in the context of the existing evidence. No guidelines can take into account all of the often compelling individual clinical circumstances.

El oxígeno y/o la luz son los principales causantes de la degradación de los componentes de la nutrición parenteral (NP), especialmente de vitaminas y lípidos. La oxidación de algunas vitaminas y la peroxidación lipídica son catalizadas por la luz, siendo la presencia de oxígeno el factor decisivo del proceso. El material de la bolsa en contacto con la NP debe ser químicamente inerte, como el etilvinilacetato (EVA) o el polipropileno. El cloruro de polivinilo (PVC), además de ceder a los lípidos el plastifi cante tóxico dietilhexilftalato (DEHP), también adsorbe otros componentes de la NP.