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1. Intravenous commercial heparin produces a lymphocytosis in the calf. The effect is not due to the preservative commonly present in heparin. 2. The lymphocytosis is mediated to a great extent by an increased input of lymphocytes into the blood via the thoracic duct. 3. The necessity of considering, plus controlling the heparin effect on blood lymphocyte levels and on the output of thoracic duct lymphocytes in all studies on lymphocyte production, migration and behavior, is discussed and emphasized.

1. A method for extracorporeal irradiation of the circulating blood has been developed. 2. Extracorporeal irradiation of the blood will produce a lymphopenia promptly which persists for weeks. 3. Heparin in high doses in the calf produces a lymphocytosis and neutrophilic leukocytosis.

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