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Background: Blood transfusion is a life-saving procedure as even a single unit of blood and its components can save multiple recipients in need. Though it's a safe procedure, the risk of transmission of infections like HIV, syphilis, hepatitis B and hepatitis C are still seen. The objective of this study was to determine the frequency of HBsAg, HCV, HIV, Syphilis and Malaria in various ABO and Rh (D) blood groups donors.Methods: A retrospective study was performed from January 2014 to May 2017 in a blood bank of a tertiary care hospital. A total of 8260 blood units which were collected from both voluntary and replacement donors during the study period were included. Complete donor's demography and screening status forTransfusion Transmitted Infections(TTI's) were analysed. Results:Out of 8260 blood donors, 232(2.8%) were positive for TTIs.The overall prevalence of HIV, HBV, HCV and Syphilis was found to be 0.06%, 2.1 % , 0.15% and 0.4% respectively. The highest percentage of prevalence was observed for HBV, followed by syphilis, HCV and HIV. Higher seroprevalence of TTI's were noted in replacement donors and younger age group between 18 to 30 years. Conclusion:Following strict donor eligibility criteria and effecting high sensitive screening methods can bring down the prevalence of TTI's. Proper treatment and follow-up counselling can help in preventing further transmission of infections in the community.