Background: Breast cancer is the most common cause of death in women by neoplasia. Plasma D-dimer is a hypercoagulability and fibrinolytic system marker, which is produced when factor XIIIa (a cross-linked fibrin) is degraded by plasmin. It is increased in various solid tumour patients including breast, lung, prostate, cervical and colorectal cancers.Methods: 30 patients of breast carcinoma who underwent radical mastectomy (cases) and 30 cases without carcinoma (controls) were included. The baseline parameters (D-dimer levels) were measured in both cases and controls. From each patient, whole blood was collected and Quantitative D-dimer levels were obtained by Diazyme's D-dimer Assay using the instrument, RANDOX Rx imola. Other parameters such as histopathological features, hormonal receptors (ER & PR) and HER2/neu status were studied in cases.Result: Mean plasma D-dimer levels were significantly higher in patients with breast carcinoma before surgery as compared to after surgery (p<0.001). Quantitative D-dimer levels highly correlated with lymph node status and histopathological grading (p=0.003, p=0.015 respectively). Conclusion:Our study showed that high plasma D-dimer levels can be used as a marker for lymph node involvement and higher histopathological grade. Due to the ease with which plasma D-dimer levels can be obtained and its cost effectiveness, quantitative D-dimer levels can be added to models for predicting axillary lymph node involvement.

Introduction: Airway hyper-responsiveness due to biochemical effects of adipose tissue related cytokines and adipokines, and mechanical changes in lung function due to obesity play an important role in outcome of asthma in obesity. In this study we correlate the severity of asthma and body mass index. Methods: Cross-sectional- observational study including 78 patients with bronchial asthma confirmed by history, physical findings and pulmonary function test attending Father Muller Medical College Hospital during November 2018- December 2019. Results Among 78 patients 27 (34.7%) had normal Body Mass Index (BMI), 35 (44.4%) were overweight and 16 (20.8%) were obese. Out of 35 overweight patients 15(46.8%) had uncontrolled asthma and 17(53%) had partly controlled asthma. Out of 16 obese patients 13(86.6%) had uncontrolled asthma and 2(13.3%) had partly controlled asthma. There was a significant correlation between BMI and asthma control with p – value <0.05. Conclusion: Partly controlled and uncontrolled asthma were partly associated with overweight and obesity. There is a need for further studies to demonstrate the effect of weight reduction in asthma control