One of the requirements for existing personal computers, PCs, is that the hardware inside must maintain an operating temperature as low as possible. One way to achieve that is to place the hardware components at locations with enough airflow around it. However, the relationship between the airflow and temperature of the components is unknown before they are placed at specific locations inside a PC. In this work a Computational Fluid Dynamics (CFD) analysis is coupled to a Design of Experiment (DOE) methodology to answer typical minitower key questions: a) how do the possible positions of hardware components affect their temperature?, and b) is it possible to get an optimal placement for these hardware components using the data collected by the CFD simulation results? The DOE methodology is used to optimize the analysis for a very large number of possible configurations. The results help in identifying where the efforts need to be placed in order to optimize the positioning of the hardware components for similar configurations at the designing stage. Somehow the results show that general conclusions could be drawn, but that there are not specific rules that could be applied to every configuration.