This paper reports for the first time the electrogenerated chemiluminescence (ECL) behavior of graphite-like carbon nitride (g-C(3)N(4)) with K(2)S(2)O(8) as the coreactant. The possible ECL reaction mechanisms are proposed. The spectral features of the ECL emission and photoluminescence (PL) of g-C(3)N(4) are compared, and their resemblance demonstrates that the excited states of g-C(3)N(4) from both ECL and photoexcitation are the same. The effects of K(2)S(2)O(8) concentration, pH, g-C(3)N(4)/carbon powder ratio, and scan rate on the ECL intensity have been studied in detail. Furthermore, it is observed that the ECL intensity is efficiently quenched by trace amounts of Cu(2+). g-C(3)N(4) is thus employed to fabricate an ECL sensor which shows high selectivity to Cu(2+) determination. The limit of detection is determined as 0.9 nM. It is anticipated that g-C(3)N(4) could be a new class of promising material for fabricating ECL sensors.

In this paper, the anodic electrogenerated chemiluminescence (ECL) behavior of graphite-like carbon nitride (g-C3N4) is studied using cyclic voltammetry with triethanolamine (TEA) as a coreactant. The possible anodic ECL response mechanism of the g-C3N4/TEA system is proposed. Furthermore, it is observed that the anodic ECL signal can be quenched efficiently in the presence of rutin, on the basis of which a facile anodic ECL senor for the determination of rutin is developed. This ECL sensor is found to have a linear response in the range of 0.20-45.0 μM and a low detection limit of 0.14 μM (at signal-to-noise of 3). These results suggest that semiconductor g-C3N4 has great potential in extending the application in the ECL field as an efficient luminophore.

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The aberrant aggregation of amyloid-β peptide (Aβ) in the brain has been considered as the major pathological hallmark of Alzheimer's diseases (AD). Inhibition of Aβ aggregation is considered as an attractive therapeutic intervention for alleviating amyloid-associated neurotoxicity. Here, we report the near-infrared light (NIR)-induced suppression of Aβ aggregation and reduction of Aβinduced cytotoxicity via porphyrinic metal-organic framework (MOF) PCN-224 nanoparticles. PCN-224 nanoparticles are hydrothermally synthesized by coordinating tetra-kis(4carboxyphenyl)porphyrin (TCPP) ligands with zirconium. The PCN-224 nanoparticles show high photo-oxygenation efficiency, good biocompatibility, and high stability. The study reveals that the porphyrinic MOF-based nanoprobe activated by NIR light could successfully inhibit self-assembly of monomeric Aβ into a β-sheet-rich structure. Furthermore, photoexcited PCN-224 nanoparticles also significantly reduce Aβ-induced cytotoxicity under NIR irradiation.