Brucellosis is a wide spread zoonotic bacterial disease of humans and animals. In humans the disease is recognized commonly as undulant fever, characterized by headache malaise, and arthritis. Brucellosis can occur in any age group, but mainly found in young men between the ages of 20 and 40 years because of occupational hazards. Domestic animals (cattle, sheep and goat, pigs, dogs etc) are highly susceptible to brucellosis.  Generally, brucellosis manifest in female animals as abortion, retained placenta, stillbirth and death of young ones soon after birth. In males, the  main features are vesiculitis, orchitis, and epididymitis, which may render infected male infertile for life. The endemicity of brucellosis has remained  a threat in low- income countries of sub-Saharan Africa and South Asia and has multiple economic implications across agriculture and public health  sectors, and broader implications on economic and social development sectors. Google and Google Scholar were used to retrieve articles used for  this review, which included published research articles and local, national and international reports on brucellosis. In this review, we summarised  human and animal brucellosis, prevalence of infections in Nigeria, and economic impacts on production. It is believed that this review will guide  researchers on the state of brucellosis in developing countries where the disease is still endemic, using Nigeria as a case study.