Introduction: Hemodynamic instability is most commonly seen among critically ill patients in Intensive care units and it is essential to detect circulatory changes. As peripheral tissues are sensitive to alterations in perfusion, the non-invasive monitoring of peripheral circulation could be used as an early marker of systemic hemodynamic derangement. Hence, the current study was conducted to associate the peripheral perfusion status with the prognostic significance among mechanically ventilated patients. Methodology: A Descriptive research design was conducted in Intensive care unit at Saveetha Medical College and Hospital with 60 samples selected using Convenience sampling technique who matched inclusion criteria. Results: The study results had shown that, Prognosis had a significant association between level of peripheral perfusion among mechanical ventilated patients at p<0.001.The demographic variables of age (χ2=9.364, p=0.023), history of smoking (χ2=4.220, p=0.040) and the clinical variables of ventilator mode (χ2=4.169, p=0.032), illness severity score on the day of admission (χ2=13.310, p=0.021), SPO2 (χ2=7.367, p=0.025), and Lactate levels (χ2=5.372, p=0.043) had shown statistically significant association with level of peripheral perfusion status at p<0.05.Conclusion: Monitoring peripheral perfusion not only provides a different point of reference to reflect a disturbance of the circulation but it also does not require invasive techniques and can be used directly at the bedside. Furthermore, peripheral perfusion status has an impact on prognosis of the patient.