Plasma concentrations of ET in patients with PAD are greatest in early disease; ET concentrations decrease substantially and inflammation arises as disease advances. Serum CRP concentrations exhibit a modest negative correlation with those of ET.

Treatment with statins lowers plasma nitrite and CRP levels in patients with PAD. Our data support the effects of statins in vivo that have been demonstrated on the endothelium ex vivo, suggesting a beneficial effect by acting on the initial processes that trigger the disease, reducing oxidative stress (increase in the bioavailability of nitric oxide as peroxynitrite levels decrease) and curtailing the inflammatory processes which perpetuate the disease.

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Conclusion-According to generally accepted criteria in surgical treatment the majority of the CLI patients required either the enteral or the parenteral nutrition before the planned surgical intervention. The data presented here shows tremendous importance of the nutritional treatment in the holistic treatment of the CLI patients.