Past attempts to relate mechanical properties of the stratum corneum to its state of hydration or disease condition have been hampered by the lack of adequate in vivo methodology. With the technique described herein, viscoelastic properties of the skin surface can be measured in vivo or on excised skin in vitro. This method is sensitive enough to detect changes in the properties of the stratum corneum induced by topically applied agents or by mechanical disruption of it. The viscoelastic data suggest that the outermost layers of the stratum corneum may become dry in vivo despite their proximity to the underlying wet tissue, and that the instrument is sensitive enough to measure the changes that occur. It also appears that the in vivo behavior of the stratum corneum is similar to that of isolated stratum corneum membranes which become brittle when they are dried and supple when they are hydrated.

This paper summarises a comprehensive Monte Carlo simulation study for precision resonance energy scan measurements. Apart from the proof of principle for natural width and line shape measurements of very narrow resonances with PANDA, the achievable sensitivities are quantified for the concrete example of the charmonium-like X(3872) state discussed to be exotic, and for a larger parameter space of various assumed signal cross-sections, input widths and luminosity combinations. PANDA is the only experiment that will be able to perform precision resonance energy scans of such narrow states with quantum numbers of spin and parities that differ from J P C = 1 −− .

High-performance cluster-jet targets are ideally suited and applied since years in hadron and laser plasma physics. Therefore, the forthcoming MAGIX experiment at the future energy recovering electron accelerator MESA will use a cluster-jet target to perform high precision measurements on electron scattering experiments, i.e., determination of the proton radius. For this purpose, a clusterjet target was designed, built up and set successfully into operation at the University of Münster considering the requirements of the experimental setup of MAGIX. The details on these requirements, calculations to their realization, e.g., on the nozzle geometry and stagnation conditions of the target gas, their technical implementation and the features of the target which make the target a powerful state-of-the-art target, are highlighted in this publication. Furthermore, the measured and analysed jet beam characteristics from this target using a Mach Zehnder interferometer are presented and discussed. These are of highest interest for the final design of the complete experimental setup of MAGIX. Moreover, first measurements from commissioning beam times performed with the target installed at the already running MAinzer MIkrotron will be presented.

The antiproton experiment PANDA at FAIR is designed to bring hadron physics to a new level in terms of scope, precision and accuracy. In this work, its unique capability for studies of hyperons is outlined. We discuss ground-state hyperons as diagnostic tools to study non-perturbative aspects of the strong interaction, and fundamental symmetries. New simulation studies have been carried out for two benchmark hyperon-antihyperon production channels: $${\bar{p}}p \rightarrow {\bar{\varLambda }}\varLambda $$ p ¯ p → Λ ¯ Λ and $${\bar{p}}p \rightarrow {\bar{\varXi }}^+\varXi ^-$$ p ¯ p → Ξ ¯ + Ξ - . The results, presented in detail in this paper, show that hyperon-antihyperon pairs from these reactions can be exclusively reconstructed with high efficiency and very low background contamination. In addition, the polarisation and spin correlations have been studied, exploiting the weak, self-analysing decay of hyperons and antihyperons. Two independent approaches to the finite efficiency have been applied and evaluated: one standard multidimensional efficiency correction approach, and one efficiency independent approach. The applicability of the latter was thoroughly evaluated for all channels, beam momenta and observables. The standard method yields good results in all cases, and shows that spin observables can be studied with high precision and accuracy already in the first phase of data taking with PANDA.

This paper reports on Monte Carlo simulation results for future measurements of the moduli of time-like proton electromagnetic form factors, $$|G_{E}|$$ | G E | and $$|G_{M}|$$ | G M | , using the $$\bar{p} p \rightarrow \mu ^{+} \mu ^{-}$$ p ¯ p → μ + μ - reaction at $$\overline{\text {P}}\text {ANDA}$$ P ¯ ANDA (FAIR). The electromagnetic form factors are fundamental quantities parameterizing the electric and magnetic structure of hadrons. This work estimates the statistical and total accuracy with which the form factors can be measured at $$\overline{\text {P}}\text {ANDA}$$ P ¯ ANDA , using an analysis of simulated data within the PandaRoot software framework. The most crucial background channel is $$\bar{p} p \rightarrow \pi ^{+} \pi ^{-}$$ p ¯ p → π + π - , due to the very similar behavior of muons and pions in the detector. The suppression factors are evaluated for this and all other relevant background channels at different values of antiproton beam momentum. The signal/background separation is based on a multivariate analysis, using the Boosted Decision Trees method. An expected background subtraction is included in this study, based on realistic angular distributions of the background contribution. Systematic uncertainties are considered and the relative total uncertainties of the form factor measurements are presented.