Objective: To investigate the efficacy of stimulation at the Jing-Well points of meridians in advanced clinical practice. Methods: Articles including English or Chinese keywords on the Jing-Well points of meridians published between 2001 and August 2012 were sourced from the Cochrane Library, PubMed, and China National Knowledge Infrastructure databases. On the basis of these reports, we explored the modern applications, mechanisms, and efficacy of the Jing-Well points. Results: Thirty-five related studies, published mainly in Chinese, were identified. Evidence was found to support the use of Jing-Well point stimulation in the treatment of stroke, persistent vegetative status, severe head injury, vascular dementia, Alzheimer's disease, upper respiratory infection, bronchial asthma, hysterical aphonia, postpartum lactation insufficiency, fetal malpresentation, dysmenorrhea, acne, sudden deafness, sleeping disorders, and post-chemotherapy nausea and vomiting. Conclusion: Diseases associated with the 12 meridians and meridional dermomeres (十二皮部) can be treated by stimulating the related Jing-Well points. Stimulation of all the Jing-Well points can activate and restore function in the damaged brain. Rigorous high-quality trials are needed to improve the level of evidence on their effectiveness and safety.

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