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Osteoporosis awareness is essential for preventing osteoporotic fractures. Social media platforms have enormous potential to both support and deter patients' decisions on healthcare. The current study demonstrated that the majority of YouTube videos on osteoporosis provide useful information with sufficient quality. Purpose YouTube is the most popular video-sharing platform for patients seeking online information about their medical condition. However, there are concerns regarding the accuracy and quality of YouTube content. We aimed to analyze the quality of English-language YouTube videos on osteoporosis. Methods A YouTube search was performed on April 21, 2021, using the keywords "osteoporosis," "osteoporosis exercise," "osteoporosis diet," and "osteoporosis treatment." The reviewers recorded the content, source, and detailed characteristics of the included videos. The reliability and quality of the videos were analyzed using the modified DISCERN score and Global Quality Scale (GQS) score by a rheumatologist and endocrinologist. Results Of the 400 videos screened, 238 were included in the study after applying the exclusion criteria. A total of 205 (86.1%) videos revealed useful information about osteoporosis whereas 33 (13.9%) were misleading. In terms of quality, 48% of the videos were of high quality, 34% were of moderate quality, and 18% were of low quality. The videos posted by universities and professional organizations had the highest modified DISCERN and GQS scores indicating high reliability and quality. Conclusion This study demonstrated that the majority of YouTube videos on osteoporosis contained useful information with sufficient quality. However, physicians should be aware of misleading information and correct any misinformation during face-to-face meetings with patients. YouTube should consider creating partnerships with professional organizations in the field of osteoporosis to produce high-quality videos in line with their new health content policy.

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