The World Health Organization (WHO) has given people various protective warnings for Monkeypox. If monkeypox spreads rapidly, it becomes a serious public health problem. In this case, it creates a serious congestion in hospitals. Therefore, auxiliary systems can be needed in hospitals. In this study, explainable artificial intelligence (xAI) assisted convolutional neural networks (CNNs) based a decision support system was proposed. The data set was used for this task consists of 572 images in two classes, such as Monkeypox and Normal. 12 different CNN models were used for Monkeypox and Normal skin classification. MobileNet V2 model achieved best performance with the accuracy of 98.25%, sensitivity of 96.55%, specificity of 100.00% and F1-Score of 98.25%. This model was supported by explainable AI methods. As a result, an artificial intelligence (AI) assisted auxiliary diagnosis system has been proposed for Monkeypox skin lesion.

Stroke was the cause of one out of every six deaths from cerebrovascular disease in 2020. A stroke occurs in the United States (US) every 40 seconds. Every 3.5 minutes, people die of a stroke. More than total 795,000 stroke cases occur yearly in the US. This study aims to detect the ischemic stroke lesion that occurs in the brain. The Ischemic Stroke Lesion Segmentation (ISLES) 2017 data set, which includes 82 Magnetic Resonance images of 43 patients, was used. The UNet, Attention UNet, Residual UNet, Attention Residual UNet, and Residual UNet++ segmentation networks were tested. Moreover, Cross Entropy, Dice, IoU, Tversky, Focal Tversky, and their compound forms were analyzed. The IoU loss function tested on Attention UNet achieved the best performance with the dice score of 0.766, the IoU score of 0.621, the sensitivity of 0.730, the specificity of 0.997, the precision of 0.805, and the accuracy of 0.993.

The pancreas is one of the small size organs in the abdomen. Moreover, anatomical differences make it difficult to detect the pancreas. This project aims to automatically segmentation of pancreas. For this purpose, NIH-CT82 data set, which includes CT images from 82 patients was used. U-Net which is state-of-the-art model and its different versions, namely Attention U-Net, Residual U-Net, Attention Residual U-Net, and Residual U-Net++ were tested. Best predict performance was achieved by Residual U-Net with the dice of 0.903, IoU of 0.823, sensitivity of 0.898, specificity of 1.000, precision of 0.908, and accuracy of 0.999. Consequently, an artificial intelligence (AI) supported decision support system was created for pancreas segmentation.

Skull stripping has an important in neuroimaging workflow. Skull stripping is a time-consuming process in the Magnetic resonance imaging (MRI). For this reason, skull stripping and brain segmentation are aimed in this study. For the this purpose, the U-NET architecture design, which is one of the frequently used models in the field of medical image segmentation, was used. Also, different loss functions such as Cross Entropy (CE), Dice, IoU, Tversky, Focal Tversky and their compound forms were tested on U-Net architecture design. The compound loss function of CE and Dice loss functions achieved the best performace with the average dice score of 0.976, average IoU score of 0.964, sensitivity of 0.972, specificity of 0.985, precision of 0.960 and accuracy of 0.981. As a result, skull stripping was performed to facilitate the detection of brain diseases.

Kidney diseases are one of the most common diseases worldwide and cause unbearable pain in most people. In this study aims to detecting the cyst and stone in the kidney. For the this purpose, YOLO architecture designs were used for detection of kidney, kidney cyst and kidney stone. The YOLO architecture designs were supported by the explainable artificial intelligence (xAI) feature. CT images in three classes, namely 72 kidney cysts, 394 kidney stones and 192 healthy kidneys were used in the performance analysis part of the YOLO architecture designs. As a result, YOLOv7 architecture design outperformed the YOLOv7 Tiny architecture design. YOLOv7 architecture design achieved the mAP50 of 0.85, precision of 0.882, sensitivity of 0.829 and F1 score of 0.854. Consequently, deep learning based xAI assisted computer aided diagnosis (CAD) system was developed for diagnosis of kidney diseases.