Over the years, catfish production in Indonesia has continued to increase in line with consumer demand. Based on data from DGT (Bureau of Aquaculture), the average increase of annual catfish production is 13.75%. For instance, in 2016 the catfish production target was 1,217 tons, while 3 years later (2019) the target was 1,770 tons. Catfish consumption is very popular in Indonesia, because it tastes good at a relatively low price, compared to other freshwater fish. To achieve production targets, technological innovations are carried out in catfish farming, including intensive cultivation through increasing the stocking density of fish (Pratiwi et al., 2020).Intensive catfish (Clarias gariepinus) cultivation uses high stocking densities and relatively large feeds. This causes competition in obtaining feed, fecal deposits and leftover food that has accumulated at the bottom of the pond causing water quality to decrease. Declining water quality can inhibit growth and immunity and are susceptible to disease. Diseases that commonly attack catfish are motil aeromonas septicemia (MAS), causing