IntroductionSuccessful surgical treatment of congenital heart disease improves neonates’ long-term survival and leads to catch-up growth, which however does not occur in part of the patient population for largely undetermined reasons.Methods and analysisA multicentre, prospective cohort study is being conducted in four paediatric medical institutions in China to collect detailed nutritional, anthropometric and clinical data at perioperative phases and during a 1-year period of follow-up after surgery. The study is expected to recruit approximately 5000 patients by the year of 2023 when the cohort is fully established. The primary endpoint of this study is the occurrence of postoperative catch-up growth, which will be determined in both absolute and relative terms (ie, reduced anthropometric deficits from the reference measures and improved z-scores that have passed the −2 SD cut-offs). Multivariable regression analyses will be performed to identify factors that are statistically significantly associated with the absence of postoperative catch-up growth.Ethics and disseminationThe protocol of this study has been approved by the individual ethics committees of the participating centres (Guangzhou Women and Children’s Medical Centre (2008071601), the Children’s Hospital of Zhejiang University School of Medicine (2018-IRB-094), Gansu Provincial Maternity and Child-Care Hospital (2019-IRB-01) and Zhengzhou Cardiovascular Hospital (2019012001)). Written informed consent from parents will be obtained before study entry. Findings of this study will be disseminated through publications in international peer-reviewed journals and will be presented in academic conferences.

The etiology of severe acute hepatitis (SAH) in children is various. We describe the first Chinese case of severe acute hepatitis in a 22-month-old boy with the mild illness of Omicron sub-variant BA.2.38. With the application of Compound Glycyrrhizin Injection (CGI), the patient gradually recovered from acute liver injury (ALI). This case highlights the possibility of severe ALI in children with the non-critical illness of SARS-CoV-2. The management of SAH associated with the pandemic presents challenges for clinicians, and follow-up is in need. The method of differential diagnosis using limited laboratory results is of great value to the clinicians.

Background: Seafood is a good source of the essential fatty acids which has presumably beneficial effect on developing embryos and fetuses, although it is also a source of contaminants. In this context, pregnant women are face with conflicting reports on risk and benefits of seafood consumption. This study aims to assess whether the consumption of seafood during pregnancy were associated with fetal growth. Methods: This study covered 10,179 women who delivered a singleton live birth, conducted in Lanzhou, China. The clinical data including birth outcomes and maternal complications information is extracted from medical records of the participants. We also collected information from them on intake of seafood using food frequency questionnaire. Associations between seafood consumption and birth weight, birth length, and head circumference were analyzed using multiple linear regression. Results: There was a positive association between total seafood consumption and birth weight (β 7.420, P<0.001) but no association concerning birth length or head circumference. Seafood consumption was associated with decreased risk of low birth weight (OR = 0.575, 95 % CI 0.480, 0.689). The frequency of seafood consumption during pregnancy showed a trend toward a positive association with low birth weight. Significantly reduce rates of low birthweight were found in women who consumed more than 75g seafood/week during pregnancy as compared to women with no or very low intakes(P for trend 0.021). Conclusions: Maternal seafood consumption was associated with decreased risk of low birth weight and increased birth weight. This association was mainly driven by freshwater fish and shellfish. These results further corroborate the present dietary recommendation to the Chinese Nutrition Society for pregnant women. In addition, our work emphasis the value of public health advice to change dietary habits for women in inland city in China.

Sudden public health and medical education events have tested the stability of society to a great extent. The government need to strengthen capacity building, make use of system dynamic supervision, warn public health events in advance, and minimize the impact scope and related harmfulness of events. This not only facilitates the rapid mobilization of resources by the later government but also facilitates the comprehensive and detailed deployment and arrangement of decision-makers. As we all know, the Internet of Things is used by all walks of life because of its outstanding advantages of low power consumption, low cost, and wide range. Therefore, this article takes the Internet of Things as the technical basis of the system. According to the actual demand and resource design, it includes two system functions: detection and early warning. The results show that: (1) considering the practical principle, the evaluation system interface found that the scores of font size and color style are all below 80%, which need to be optimized and adjusted; the overall interface basically meets the needs of users. (2) The throughput of the three methods is different. The CoAP-E has superior throughput. (3) With the increase in packet loss rate, the request success rate of the CoAP method decreases in a “drop” manner. The CoAP-E method in this article has the best performance. (4) When the packet loss rate is 25%, the network adaptability of this method is the strongest, and the retransmission rate is less than 18%; the CoAP method is as high as 35%. (5) When the number of concurrent requests is less than 2500, there is no obvious difference between the three methods; the optimal performance of the dynamic load balancing method is 10.1 s. (6) The system comprehensively considers various factors of five site selections. The highest comprehensive score of Final Site, 5 is 8.7, which can be used as the resettlement place of emergency rescue facilities. This article starts from the characteristics and needs of public emergencies, and the final set of the system runs well. It can quickly reflect public health emergencies and medical education events. Use the most effective system functions for risk control, and maximize the analysis, organization, and coordination of events. The follow-up optimization of system details needs to be studied.

Background Seafood is a good source of essential fatty acids which has a presumably beneficial effect on developing embryos and fetuses, although it is also a source of contaminants. In this context, pregnant women are faced with conflicting reports on the risk and benefits of seafood consumption. This study aims to assess whether the consumption of seafood during pregnancy was associated with fetal growth in an inland city in China. Methods This study included 10,179 women who delivered a singleton live birth in Lanzhou, China. Seafood consumption was assessed using a Food Frequency Questionnaire. Maternal data including birth outcomes and maternal complications information is extracted from the medical records. Associations between seafood consumption and fetal growth indicators were analyzed using multiple linear regression and multiple logistic regression. Results There was a positive association between total seafood consumption and birth weight (β = 0.027, 95%CI:0.030–0.111) but no association concerning birth length or head circumference. Seafood consumption was associated with decreased risk of low birth weight (OR = 0.575, 95% CI: 0.480, 0.689). The frequency of seafood consumption during pregnancy showed a trend toward a positive association with low birth weight. Significantly reduced rates of low birth weight were found in women who consumed more than 75 g of seafood/week during pregnancy as compared to women with no or very low intakes (P for trend 0.021). A significant interaction was observed between pre-pregnancy BMI and seafood consumption on birth weight among underweight women, but not among overweight women. Gestational weight gain partially mediated the association between seafood consumption and birth weight. Conclusions Maternal seafood consumption was associated with decreased risk of low birth weight and increased birth weight. This association was mainly driven by freshwater fish and shellfish. These results further corroborate the present dietary recommendation to the Chinese Nutrition Society for pregnant women, especially those with underweight pre-pregnancy BMI and inadequate GWG. In addition, our findings provide implications for future interventions to improve seafood consumption among pregnant women to prevent low birth weight babies in the inland city in China.