Objective: To clarify the efficacy of vascular smooth muscle technology in the treatment of thin endometrial infertility, and to provide a theoretical basis for the further diagnosis and treatment of thin endometrial infertility. Methods: In accordance with the inclusion and exclusion criteria, 2015.01-2020.01 selected thin endometrial infertility patients undergoing freeze-thaw embryo transfer at the Female Pelvic Floor Urinary Reconstructive Center in Dalian Municipal Women and Children’s Medical Center were selected according to different treatment methods. For the two groups, pure estrogen therapy was used as the control group, and vascular smooth muscle technology combined with estrogen therapy was used as the study group. All patients' endometrial thickness and pregnancy and delivery were recorded before and after treatment. Results: 1. The endometrial thickness of the study group was significantly larger than that of the control group after treatment, the difference was statistically significant ( P <0.05); 2. 80 patients in the study group, 13 cases of successful pregnancy and delivery, 5 cases of biochemical pregnancy; the endometrial changes of the 50 patients in the control group was not obvious after treatment, none of the endometrial thicknesses reached the embryo transfer standard, and none were transplanted. Conclusion: Vascular smooth muscle technology can effectively increase the thickness of endometrium, with the aim of assisting to improve the pregnancy success rate of thin endometrial infertility through vascular smooth muscle technology.