Abstract:Objective: Adrenocortical carcinoma (ACC) is a rare but highly malignant tumor, and its diagnosis is mostly delayed and prognosis is poor. We report estrogen receptor (ER) expression in this tumor and our clinical experiences with 17 ACC cases. Methods: The data of the 17 patients (9 females and 8 males, age range from 16 to 69 years, mean age of 42.6 years) with ACC were reviewed, and symptoms, diagnostic procedures, treatment, and results of follow-up were evaluated. Immunohistochemistry was used to detect ER expression in tumor samples from the 17 patients. Results: At the time of diagnosis, 4 tumors were classified as Stage I, 4 as Stage II, 3 as Stage III, and 6 as Stage IV. Eight patients demonstrated positive nuclear immunostaining of ER. The prognosis of patients with ER positive was significantly better (P<0.05) than that of patients with ER negative, with 1-and 5-year survival rates at 86% and 60% for ER-positive patients, and 38% and 0% for ER-negative patients, respectively. Conclusion: ER-positivity may be one of the factors associated with a worse prognosis of ACC.

In order to solve the problem of mechanical professional courses classroom boring, designed a new interest linkage mechanical mechanism demonstration teaching aid. The teaching aid comprises five sets of mechanical mechanism, respectively, gear mechanism, Geneva mechanism, slider crank mechanism, an eccentric wheel mechanism and a crank rocker mechanism, the linkage mechanism device to run a series of each mechanism are mounted in a plastic box, the demonstration started general switching power supply, the small ball rolling into the box through the rubber hose, connected circuit, the electromagnetic lock electric lock indent, frame and a mechanism that plate falling, plate engraved with the mechanism of description, teaching effect. The plate falling touch stroke switch, the motor power, operation mechanism, for each mechanism are equipped with relay, so after a period of time will make the organization a power operation, in the same way, until finally a mechanism. The teaching aid has strong interest, is beautiful and practical, easy to use, and has good practical value.