The quantitative analysis of the left ventricle (LV) contractile function is one of the key steps in the assessment of cardiovascular disease. Such analysis greatly depends on the accurate delineation of LV boundary from cardiac sequences. However, segmentation of the LV still remains a challenging problem due to its subtle boundary, occlusion, and image inhomogeneity. To overcome such difficulties, the authors propose a novel segmentation method by incorporating a dynamic shape constraint into the weighting function of the random walks segmentation algorithm. This approach involves iterative updates on the intermediate result to achieve the desired solution. The inclusion of a shape constraint restricts the solution space of the segmentation result to handle misleading information that may come from noise, weak boundaries and clutter, leading to increased robustness of the algorithm. The authors describe the details of the proposed method and demonstrate its effectiveness in segmenting the LV from real cardiac magnetic resonance (CMR) image sets. The experimental results demonstrate that the proposed method obtains better segmentation performance than the standard method.

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Evaluation of right ventricular (RV) structure and function is of importance in the management of most cardiac disorders. But the segmentation of RV has always been considered challenging due to low contrast of the myocardium with surrounding and high shape variability of the RV. In this paper, we present a 2D + T active contour model for segmentation and tracking of RV endocardium on cardiac magnetic resonance (MR) images. To take into account the temporal information between adjacent frames, we propose to integrate the time-dependent constraints into the energy functional of the classical gradient vector flow (GVF). As a result, the prior motion knowledge of RV is introduced in the deformation process through the time-dependent constraints in the proposed GVF-T model. A weighting parameter is introduced to adjust the weight of the temporal information against the image data itself. The additional external edge forces retrieved from the temporal constraints may be useful for the RV segmentation, such that lead to a better segmentation performance. The effectiveness of the proposed approach is supported by experimental results on synthetic and cardiac MR images.