The objective of this study was to treat biological ammonium and organic matter from milk manufacturing wastewater in Binh Dinh using combined biofilter and plant process. The treatment efficiency of biofilter-plant method in section biosysterm was higher than that of individually biofilter and plant method to be observed. The obtained experiment results showed that the outflowing physico-chemical parameters as COD, NH4+ of milk production wastewater after treatment by the combined use of biofilter and plant treatment reached QCVN 40: 2011/BTNMT for industrial wastewater sort A.