Injuries to the anterior cruciate ligament (ACL) of the knee are one of the most prominent injuries affecting players in American football. One primary aim of training to reduce injury risk is to provide exercises for players on attaining the highest athletic performance with the least orthopedic stress. This review article on ACL injury reduction protocols focuses on the protective and performance-enhancing biomechanical patterns during simple exercises used in a gym-based setting, in the following areas: single-leg balance and trunk stability, single-leg jumping/plyometrics, and reflexive strength training. This supplementary training, as part of a sports performance program, might include training to develop maximum strength, explosive power, acceleration, maximum velocity, bioenergetic endurance qualities, mobility/flexibility, agility, and sport skill acquisition.