with breast cancer under the age of 50-years (approximately 49,000 women) and is a leading cause of death in this age group [1]. It is estimated that over 40,000 women will die of this disease in 2015 [2]. More than 50% have estrogen-receptor positive (ER+) disease, although estrogen is a steroid sex hormone required for normal breast development [3]. There is a strong correlation between exposure to estrogen and development of breast cancer [3,4]. Breast cancer due to elevated blood levels of estrogen is the most frequent type of invasive malignancy that affects over 1 million women worldwide [4]. Breast carcinogenesis is due to metabolism of estrogen to genotoxic metabolites and cellular growth and proliferation that leads to initiation, promotion and development of breast cancer [5].
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