Colombia es reconocida en la región por la universalidad tanto de su sistema de salud como de sus sistemas de información. Si bien el Sistema de Información Integral para la Protección Social (SISPRO) tiene como finalidad cumplir una función administrativa dentro del sistema de salud, se están reconociendo sus usos en investigación. SISPRO está compuesto por varias bases de datos diferentes: las estadísticas vitales, el registro individual de prestaciones en salud (RIPS) y la clasificación única de trámites en salud (CUPS), entre otras. Las estadísticas vitales registran los nacimientos y las defunciones, junto con la ubicación geográfica, la edad de la madre o la causa de la muerte, entre otra información. Los RIPS son la base de datos más utilizada en investigación en salud, ya que permiten establecer el número de contactos que las personas tienen con el sistema de salud (más de 2 mil millones en el último quinquenio) y conocer los principales diagnósticos registrados en cada uno de estos contactos. Con RIPS, ha sido posible establecer la prevalencia de esclerosis múltiple o estimar la carga de enfermedad de la epilepsia en Colombia. RIPS también tiene información útil sobre el costo de la atención médica. Finalmente, los CUPS permiten cuantificar los procedimientos de salud, por ejemplo, podemos estimar en 1879 el número de procedimientos de trombólisis de vasos intracraneales en Colombia entre 2017 y 2021. La calidad de la información es una gran limitación en toda base de datos administrativa, sin embargo, SISPRO representa una gran oportunidad para utilizar los registros oficiales para generar conocimiento, comprender la distribución geográfica de las enfermedades y contribuir al diseño de políticas públicas en nuestra población.
Reversible cerebral vasoconstriction syndrome (RCVS) is characterised by severe thunderclap headaches (with or without the presence of acute neurological symptoms) and segmental vasoconstriction of cerebral arteries that resolves spontaneously in a period of three months. Cases have been described in the literature with producing and non-producing masses of metanephrines. Within these reports, associations with cavernous haemangioma, medulloblastoma, colon cancer, paraganglioma, pheochromocytoma, uterine fibroids, among others were found. However, no association with adrenal masses which do not produce metanephrines was found. In this context, we reported the case of a woman with this type of tumour associated with RCVS which provided a treatment challenge, as well as we reviewed the literature on cases of RCVS associated with masses.
Non‐infectious encephalitis has been a recognized entity for many years; however, its pathophysiology was not fully understood. Patients (usually women) presented with acute behavioral changes and were admitted to mental hospitals, without a correct diagnosis. With the new advances on antibody detection, the non‐infectious encephalitis panorama has been changing. Immune‐mediated diseases of the central nervous system encompass a variety of disorders, including the classic paraneoplastic encephalitis and the more recently discovered autoimmune encephalitis. Recognition of the new syndromes and antigens, in addition to the advances in diagnostic methods, such as antibody detection and imaging, and early implementation of immunotherapy, have changed the field of autoimmune encephalitis significantly over the past two decades. The best recognized form of autoimmune encephalitis is anti‐N‐methyl‐D‐aspartate receptor encephalitis, which usually presents with neuropsychiatric changes, seizures, autonomic dysfunction and usually a decreased level of consciousness. Nevertheless, the panorama for other types of receptors, such as anti‐α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor, anti‐gamma‐aminobutyric acid and, most recently, anti‐glycine receptor, anti‐metabotropic glutamate receptor 5, dopamine receptor D2 and dipeptidyl‐peptidase‐like protein 6, which can present clinically as encephalitis, is currently changing, meaning that the panorama for diagnosis and treatment is broadening every day.
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