BioGPS is a community based customisable gene annotation portal bringing together gene annotation resources on to a single platform.

This manuscript describes the creation of comprehensive gene wiki, seeded with data from public domain sources, which will enable and encourage community annotation of gene function.

No abstract

7,8,8] naphthyridine-3-carboxylate (ITH4012) is a novel tacrine derivative that can reduce cell death induced by various compounds with different mechanisms of action, such as thapsigargin (reticular stress), H 2 O 2 (free radicals), and veratridine (calcium overload), in bovine chromaffin cell. Cell viability, quantified as lactic dehydrogenase release, was significantly reduced by ITH4012 at concentrations ranging from 0.01 to 3 M. In the human neuroblastoma cell line SH-SY5Y, ITH4012 also reduced amyloid ␤ 25-35 -induced apoptosis, determined by flow cytometry. ITH4012 caused a slight elevation in the cytosolic concentration of Ca 2ϩ in fura 2-loaded bovine chromaffin cells, which could be related to the induction of protein synthesis relevant for cell survival. Blockade of protein synthesis by cycloheximide or blockade of Bcl-2's active site with HA14-1 (ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate) reversed the cytoprotective action of ITH4012. Furthermore, exposure of bovine chromaffin cells for 24 or 48 h to neuroprotective concentrations of this compound enhanced, nearly 3-fold, the expression of the antiapoptotic protein Bcl-2. In conclusion, ITH4012 is a tacrine derivative that maintains acetylcholinesterase-inhibiting activity (IC 50 ϭ 0.8 M) but has the additional property of acting as a calcium promotor, a property leading to neuroprotection through the induction of antiapoptotic proteins.Alzheimer's disease (AD) is a degenerative disorder of the central nervous system found primarily among the aged. It is the most common type of dementia in western societies and has been creating profound economic and social impacts as the elderly population continues to increase (Guttman et al., 1999). The hallmarks of the illness are extracellular deposition of neuritic plaques of amyloid-␤ peptide (A␤), intracellular formation of neurofibrillary tangles, and selective neuronal loss. Of all biochemical changes observed in AD patients, only the reduction in number of functional neuronal nicotinic receptors is related to neuropsychiatric symptoms (Schroder et al., 1991). For this reason, the only pharmacotherapeutical strategy that, until now, has proven to have some efficacy in slowing progression of the illness is that which improves cholinergic neurotransmission, counteracting the deficit of cerebral acetylcholine (Standaert and Young, 1996). Therefore, acetylcholinesterase inhibition is currently the therapeutic strategy most commonly used to treat Alzheimer's patients.On the other hand, moderate chronic depolarization has demonstrated an ability to increase the survival of different neuronal types. Also, there is evidence that this effect is mediated by the mild and sustained elevation of [Ca 2ϩ ] c ,

Este estudio fue desarrollado con el objetivo de analizar los indicadores bibliométricos de producción de seis revistas de psicología en Colombia durante el período 2009-2011, para lo que se definieron las propiedades de las redes de colaboración científica entre los autores e instituciones. Para ello, se realizó la estandarización de la información relacionada con los artículos publicados en cada una de las revistas, se definieron los índices de producción de acuerdo con criterios bibliométricos (número de artículos y autores, áreas de publicación, tipo de producción, entre otros), se calcularon indicadores estructurales de las redes y se diseñaron visualizaciones de las redes de cooperación científica. Se destaca una producción amplia en países como Colombia, España y México, esencialmente en español, con resultados de investigación aplicada. Se observó un nivel elevado de colaboración entre autores.