Amaç: Psoriasis, üzerinde sedefi-beyaz renkli skuamlar bulunan eritemli plak veya papüllerle seyreden kronik, inflamatuar bir dermatozdur. Normal popülasyonda %1-2 arasında görülür. Biz bu çalışmada bölgemizdeki psoriasis hastalarının klinik ve demografik özelliklerini sunmayı amaçladık. Gereç ve Yöntemler: Mayıs 2006 ile Nisan 2010 tarihleri arasında psoriasis polikliniğimizde takip edilen 640 hasta geriye dönük olarak değerlendirildi. Bulgular: Polikliniğimize başvuran hastaların %0.7'sini psoriasis tanılı hastalar oluşturmaktaydı. Hastaların 321'i kadın, 319'u erkekti. Hastaların %25.6'sında birinci veya ikinci derece akrabalarından en az birinde psoriasis öyküsü mevcuttu. Hastalarda en sık eşlik eden sistemik hastalık hipertansiyon idi. Hastaların %97.6'sı psoriasis vulgaris, %2.3'ü püstüler psoriasis idi. Tırnak bulgusu hastaların %37.6'sında psoriatik artrit ise %5.6'sında saptandı. Sonuç: Çalışmamızda psoriasis ile ilgili klinik ve demografik özellikler Türkiye'de yapılan diğer çalışmalar ve Avrupa toplumlarıyla benzer bulunmuştur. Kadın/erkek oranı eşittir. Psoriasisin en yaygın tipi plak tip olup en sık görülen tırnak bulgusu pittingdir. Hastalığın başlangıcı üçüncü dekatta daha sıktır. En sık görülen komorbidite hipertansiyondur. (Turk J Dermatol 2011; 5: 71-4 AbstractObjective: Psoriasis is a chronic inflammatory dermatosis with silvery-white coloured squamas and is characterized by erythematous papules and plaques. Psoriasis is seen in 1-2% of the normal population. In this study we aim to introduce the clinical and demographic features of patients with psoriasis in our region. Materials and Methods: 640 patients being followed in our psoriasis polyclinic between May 2006 and April 2010 were evaluated retrospectively.Results: Patients diagnosed with psoriasis constituted the 0.7% who visited our polyclinic. Three hundred and twenty one of the patients were female and 319 were male. A history of psoriasis was observed in at least one of the first or second degree relatives of 25.6% of patients with psoriasis. The most common concomitant disease in patients was hypertension. 97.6% of the patients had psoriasis vulgaris and 2.34% had pustular psoriasis. Nail involvement and psoriatic arthritis were detected in 37.6% and 5.62% of the patients. Conclusion: In our study, the clinical and sociodemographic features of psoriasis is found to be similar to other studies carried out in Turkey and in European societies. Female/Male ratio is equal.The most prevalent psoriasis type is plaque type and the most frequent nail finding is pitting. The onset of the disease is more widespread in the third decade. The most common comorbidity is hypertension. (Turk J Dermatol 2011; 5: 71-4)
Progresif maküler hipomelanozis (PMH) ilk olarak 1988 y›l›nda Guillet taraf›ndan tan›mlanm›flt›r. PMH s›kl›kla gövdeyi tutan, asemptomatik, zor fark edilen, numuler, skuams›z, hipopigmente maküllerle karakterizedir. PMH ço¤unlukla adölesan ve genç kad›nlarda görülür. Etyopatogenezi hala bilinmemektedir. Wood lambas› alt›nda hipopigmente maküllerde k›rm›z› foliküler florasan görünürken komflu normal deride florasan gözlenmez. PMH'nin histopatolojik bulgular› genellikle non-spesifiktir, ancak hipopigmente maküllerin melanin içeri¤inin normal deriye göre azalm›fl olmas› s›k görülen bir bulgudur. Etkili bir tedavi halen bilinmemektedir. Ancak fototerapi PMH'yi kontrol alt›na almada etkili bulunmufl olmas›na karfl›n hastal›¤›n rekürrensini önlememektedir. Biz bu makalede PMH'nin etyopatogenezi, klinik bulgular›, histopatolojisi, ay›r›c› tan›s› ve tedavi seçeneklerini derlemeyi amaçlad›k. (Türkderm 2011; 45: 62-5) Anahtar Kelimeler: Progresif maküler hipomelanozis, pigmentasyon bozukluklar› SummaryProgressive macular hypomelanosis (PMH) was initially described and named by Guillet in 1988. PMH is characterized by asymptomatic, ill-defined, nummular, non-scaly, hypopigmented macules, localized predominantly on the trunk. PMH is mostly seen in adolescents and young females. The etiopathogenesis of PMH is still unknown. The red follicular fluorescence becomes visible in the hypopigmented macules under Wood's lamp but is absent in normal adjacent skin. The histopathologic findings in PMH are usually non-specific, but a common feature is the decreased melanin content in the hypopigmented macules compared to the normal skin. No effective therapy is currently known. Phototherapy was found to be effective for the control of PMH; however, it does not prevent recurrence of the disease. In this paper, we aimed to review the etiopathogenesis, clinical findings, histopathology, differential diagnosis and treatment options of PMH. (Turkderm 2011; 45: 62-5
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