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Microwave ablation (MWA) is known as an alternative therapy to surgery to treat tumors. However, MWA-based therapy requires advanced approaches in order to prevent causing damage to healthy tissue around the tumor and selectively target the desired area. Nanoparticles are considered promising tools in biomedicine to fulfill these requirements. This study was carried out in order to analyze the effect of iron oxide nanoparticles on the temperature increment during radiofrequency ablation therapy with different salt solutions including NaCl and KCl as inorganics, and pictic acid (IP6) as organic. Iron oxide nanoparticles (IONPs) with a size of 42 nm, a surface area of 77.1 m2/g, and a high magnetic field absorption capability of 0.893 A/m were synthesized. According to the results, the magnetic nanoparticles from the IP6 solution have a higher number of charges in the recipes, and also, they reacted faster than the commercially available salt solutions like KCl and NaCl since six NaSO3 molecules are in the content of the IP6. With the absorption of 5-20 % higher electromagnetic power density depending on the content of salt solution with IP6 leads to 7-10 % temperature increase under 59 W microwave input power with 2 minutes exposure. This results show that the novelty of a dipole-dipole interaction of organic IP6 with IONPs improve the ablation performance.