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The medical literature supports that congenital juvenile xanthogranulomas behave in a fashion similar to that of juvenile xanthogranulomas of infancy or childhood. Congenital cutaneous juvenile xanthogranulomas with or without systemic involvement spontaneously regress. The varied clinical presentations in the skin may lead to misdiagnosis, inappropriate examination, and unnecessary treatments. Infants with multiple congenital cutaneous juvenile xanthogranulomas should be evaluated for systemic involvement, with a particular focus on the liver, because 72.2% of these children were found to have hepatic juvenile xanthogranulomas.

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SUMMARY Serial C reactive protein concentrations were assayed by electroimmunoassay in 41 infants. Values in most of the non-infected infants were below 0-3 mg/dl, the lower limit of detection of C reactive protein by electroimmunoassay. Eleven of 12 infants with proved sepsis (positive blood cultures) had significantly raised concentrations and one infant with recurrent pseudomonas chest infection had a raised C reactive protein concentration. High C reactive protein concentrations were also found in infants with suspected infection. Successful treatment was followed by a decrease in the C reactive protein concentration. Total white blood cell count was not as appropriate as C reactive protein determination in the early identification of bacterial infection in the newborn.