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guanidine requirement of dependent virus. This suggests that guanidine acts on virus-induced proteins by influencing their synthesis, configuration and/or function. The accompanying paper" shows that supporting virus can also cause maturation of dependent virus RNA within heterologous capsid protein. Summary.-Evidence is presented that the early enzymes induced in HeLa cells by infection with type 1 or type 2 poliovirus or Coxsackie B1 virus can support replication of the RNA of guanidine-dependent type 1 poliovirus which superinfects the same cells.

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Several group A coxsackieviruses (A13, 15, 18, and 21), but not polioviruses or group B coxsackieviruses, are rapidly inactivated in low ionic strength solutions at neutral pH. The extent of inactivation is dependent upon temperature and molarity. Virions inactivated in this manner contain a normal complement of