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The microstructure of additively manufactured (AM) metals has been shown to be heterogeneous and spatially non-uniform when compared to conventionally manufactured metals. Consequently, the effective mechanical properties of AM-metal parts are expected to vary both within and among builds. Here, we present a framework for simulating process-(micro)structureproperty relationships of AM metals produced via direct laser deposition (DLD). The framework predicts grain nucleation and competitive growth as a function of thermal history for a multi-pass, multi-layer DLD process. The resulting three-dimensional microstructure is automatically sub-sampled to perform virtual mechanical testing throughout the build domain using a parallelized elasto-viscoplastic fast Fourier transform code, accounting for grainboundary strengthening. The effective stress-strain response of each subsampled volume is automatically analyzed to extract effective mechanical properties, which are used to generate property maps showing the spatial variability of effective mechanical properties throughout the simulated build volume. As a demonstration, the framework is applied to different DLD stainless steel 316L build volumes having different process-induced microstructures. The multi-physics framework and property maps could provide a path toward qualification of AM-metal parts.

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