Background Secondary prevention after embolic stroke of undetermined source (ESUS) has not yet been established. ESUS is associated with high risk of recurrent ischemic stroke and clinically silent ischemic lesions. Secondary prevention with aspirin is the current standard therapy in ESUS patients, despite high prevalence of occult atrial fibrillation (AF). Purpose To determine whether the direct oral factor Xa inhibitor apixaban, started within 28 days after index stroke, is superior to aspirin in preventing new ischemic lesions in subjects with remote cardiac monitoring. Primary endpoint was detection of new ischemic lesions in flair and diffusion-weighted (DWI) MR imaging at 12 months follow-up. Methods The study enrolled ESUS patients with risk profile for cardiac thromboembolism (i.e., left atrium (LA) size >45 mm, spontaneous echo contrast in LA appendage, LA appendage flow velocity ≤0.2 cm/s, atrial high rate episodes, CHA2DS2-Vasc score ≥4, patent foramen ovale). Patients were randomized 1:1 into the aspirin and apixaban arms. Study drug was initiated within 3–28 days after minor/moderate stroke and 14–28 days after major stroke. MRI (Flair/DWI) was conducted within 7 days of AF detection by remote cardiac monitors and at 12 months. ClinicalTrials.gov Identifier: NCT02427126. Funding: The trial is supported by BMS-Pfizer Alliance. Results Enrollment was stopped after interims analysis (including 200 patients) due to futility. Overall, 373 patients were screened with 353 being enrolled (178 and 175 in apixaban and ASA arms, respectively). So far, 130 (73.0%) and 120 (68.6%) subjects from apixaban and ASA arms, respectively, completed the study. 2% death, 1.7% withdrawal, and 1.7% were lost to follow-up. 3.9% did not completed the study for other reasons. Mean age of the ATTICUS population was 68.5 years with 51% males. 80% of the subjects suffered from hypertension. Mean systolic blood pressure at enrollment was 132 mmHg, BMI was 27.7, and CHA2DS-VASc-Score was 4.9. So far, adverse events (AE) occurred in 63% of the subjects, 30% was documented as severe. 6.8% cases of recurrent ischemic stroke and no case of hemorrhagic stroke were reported. Only 1 case of severe bleeding was reported in the aspirin arm. Newly detected AF was reported in 80 patients (23%), 42 occurring in the aspirin arm. As required by protocol, latter were immediately switched from aspirin to apixaban. Due to ongoing data clearing, numbers and % will change until presentation. Conclusions In contrast to the recently published NAVIGATE and RESPECT ESUS trials, patients enrolled in ATTICUS need to exhibit additional AF predicting factors. Furthermore, mandatory cardiac remote monitoring will help to elucidate the impact of AF and the effects of early oral anticoagulation with apixaban compared to antiplatelet therapy with aspirin on the incidence of new ischemic lesions after ESUS. Preliminary data will be presented and discussed in the context of current literature. FUNDunding Acknowledgement Type of funding sources: Private company. Main funding source(s): The trial is supported by BMS-Pfizer Alliance.
ZusammenfassungBis zu 80% der PatientInnen vor Tumorresektionen des oberen Gastrointestinaltrakts sind mangelernährt. Dabei hat schon der präoperative Ernährungszustand einen signifikanten Einfluss auf den perioperativen Verlauf. Ein adäquater präoperativer Ernährungszustand, der unter anderem die Komplikationsrate und die Krankenhausliegedauer reduzieren kann, ist daher erstrebenswert. Zwar empfehlen einschlägige Leitlinien Maßnahmen zur Erkennung und Behandlung einer Mangelernährung, jedoch fehlt es bislang an Vorschlägen zur Planung eines strukturieren präoperativen Ernährungsmanagements auf die BehandlerInnen zurückgreifen können. Innerhalb dieser Arbeit wurden 40 Krankenhäuser in Deutschland deshalb zu individuell vorhandenen Strukturen und Maßnahmen zum präoperativen Ernährungsmanagement von PatientInnen vor Tumorresektionen des oberen Gastrointestinaltrakts befragt. Die Befragungen zeigen, dass Maßnahmen zur Erkennung und Therapie einer präoperativen Mangelernährung mehrheitlich bekannt und akzeptiert sind. So befürworten 35 der 40 TeilnehmerInnen eine präoperative Ernährungstherapie bei mangelernährten PatientInnen, 26 TeilnehmerInnen erwägen hierfür sogar einen Aufschub der Operation. Eine flächendeckende Umsetzung an den Kliniken scheitere jedoch häufig an Hinderungsgründen, wie fehlender Sichtbarkeit der Ernährung als Therapiebaustein unter BehandlerInnen, labilen Verantwortlichkeiten sowie unzureichenden finanziellen und personellen Ressourcen. Mögliche Lösungsvorschläge zum Abbau der Hindernisse reichen von Refinanzierungsmöglichkeiten der klinischen Ernährungstherapie bis hin zu Forderungen auf gesundheitspolitischer Ebene. Aus den Erkenntnissen aktueller Studien und Leitlinien, sowie den Ergebnissen der Befragung, unterbreitet diese Arbeit einen Vorschlag zur Implementierung eines präoperativen Ernährungsmanagements. Dessen Umsetzbarkeit im klinischen Alltag sollte dabei durch wissenschaftliche Verfahren begleitet werden.
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