Present study was aimed to characterize the phytochemical profile of the leaf extracts of Spondias sp and Spondias tuberose. During study total five trees of Spondias sp (Cajarana do sertão) and Spondias tuberosa (Umbu) with good phytosanitary was used for phytochemical analysis. From these selected trees total 5kg leaves per tree were collected and air dried at 40°C. These leaves samples were ground and pulverized; from this 200g of powder sample were used to prepare ethanolic crude extract and phytochemical analysis was performed at the Laboratory of Pharmaceutical Technology, Federal University of Paraíba. The phytochemical screening was carried out by preliminary scouting method for identify the presence of alkaloids, steroids, tannins, flavonoids, terpenoids, and saponins. Results of study revealed that the presence of steroids, tannins, flavonoids and terpenoids from the leaf extracts of Spondias sp and Spondias tuberosa , these phytochemicals are important constitute of herbal medicines and pharmaceutical industry and worked as antioxidant, anti-infective, anti-allergic and anti inflammatory agents.