* Aos amigos do hospital em estudo que contribuíram para a realização desse trabalho.Revista de Administração Hospitalar e Inovação em Saúde Vol. 14, n.2 ▪ Belo Horizonte, MG ▪ ABR/JUN 2017 Análise dos Resultados da Aplicação de Práticas Gerenciais na Logística de Estoque de uma Farmácia Hospitalar 15 RESUMO O presente estudo propôs como objetivo melhorar o desempenho de uma farmácia hospitalar de um hospital privado de Minas Gerais através da implementação de técnicas gerenciais, sendo os resultados monitorados por indicadores. O trabalho constitui um estudo de caso envolvendo o uso de indicadores de gestão para elaboração de plano de ação e monitoramento de resultados na logística de medicamentos e materiais médico-hospitalares. A coleta de dados foi realizada pelo próprio pesquisador no período de janeiro a dezembro de 2014. Observou-se que os indicadores de cobertura de estoque, compras de urgência, compras de não padronizados e perdas apresentaram no ano de 2014 uma redução em relação ao ano de 2013, decorrente das técnicas gerenciais aplicadas. Após implementação dos planos de intervenção, concluiu-se que mudanças como estabelecimento de um processo de programação de compras sistematizado, reestruturação do processo de padronização e gerenciamento das perdas mensais, podem amenizar diversos problemas verificados no setor, concluiu-se que alguns pontos críticos como o processo de devolução, necessitam de uma intervenção mais abrangente para que possa atingir os índices esperados.Palavras-chave: Logística. Administração Hospitalar. Indicadores de Gestão. ABSTRACTThe present study aims to improve the performance of a hospital pharmacy from a private hospital in Minas Gerais through the implementation of managerial techniques. The obtained results were monitored by these indicators. The work consists in a case study involving the use of management indicators generating as a result, an action plan and the results in the logistics of medicines and hospital materials. The data was collected by the researcher in the period from January to December 2014. It was noted that inventory coverage indicators, urgent purchases, non-standard purchases and losses presented in the year of 2014 achieved a reduction relative to the year of 2013, arising from the managerial techniques applied. After the implementation of the intervention plans, it was concluded that changes such as a process of systematical purchase program, restructuration of the process of standardization and management of monthly losses can alleviate several problems verified in the sector, it was concluded that some critical points such as the devolution process require a more comprehensive intervention so that it can reach the expected indices.

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Many evidences clearly demonstrate that Schwann cells provide trophic support for neurons. Different cytokines, including neurotrophins (NTs), are produced and released by Schwann cells. These trophic molecules play an important role on neuronal survival either during the development or during adult life. Cytokines have also a pivotal role on neuronal regeneration after lesions occurring during pathological conditions. The aim of this work was to study the effect of sciatic conditioned medium (SCM) on rat retinal cells maintained in culture. Our results show that treatment with SCM obtained after 14 days in vitro (SCM 14 day) induced a three-fold increase in protein content of the culture after 48 h in vitro and this value remained equally high up to 72 h. This effect was totally blocked either by addition of 30 microM BAPTA-AM, an intracellular calcium chelator, 15 microM fluorodeoxyuridine, an inhibitor of cell division, or 10 microM genistein (geni) plus 1.25 microM chelerythrine chloride (CC), the two last ones inhibitors of tyrosine kinases and protein kinase C, respectively. SCM induced an increase in [(3)H]-choline uptake and [(3)H]-thymidine incorporation of retinal cells. SCM also stimulated an increase in cytoplasmic processes outgrowth of retinal cells and survival of retinal ganglion cells. Our results clearly suggest that soluble molecules released by sciatic nerve fragments are able to increase the proliferation and survival of retinal cells in culture.

Since 1973, multiple effects of basic fibroblast growth factor have been described in a large number of cells. These effects include proliferation, survival and differentiation. The aim of this work was to study the intracellular pathways involved in the basic fibroblast growth factor (FGF2) effect on rat retinal cells proliferation in vitro. Our data show that treatment with FGF2 increases proliferation in a concentration- and time-dependent manner. The effect of 25 ng/ml FGF2 was blocked by 10 microM genistein, a tyrosine kinase inhibitor and by 25 microM LY294002, a PI3 kinase inhibitor. The concomitant treatment with 0.3 microM chelerythrine chloride, a protein kinase C inhibitor, and 6.25 microM LY294002 also inhibited the effect of FGF2. Our results suggest that the proliferative effect of FGF2 on retinal cell cultures involves the activation of distinct kinases.