Despite the surging demand for imports in South America in recent years, South Africa’s exports to the region have shown relatively low growth. A contributing factor is the prevalence of trade barriers between South Africa and various South American countries. The aim of this study is, firstly, to measure the trade barriers to South Africa’s exports to South America and, secondly, to identify high-potential export opportunities in the form of product-country combinations that can best surmount such barriers. The investigation, which uses a reconstructed Decision Support Model (DSM), reveals that Brazil, Argentina and Chile offer the greatest potential as export markets (in US$ terms) for South Africa, while the most promising product categories are transport-related goods, minerals, vegetables and chemicals. The results of this study should be a useful guide to South Africans planning export initiatives in South America.