The aim of this study was to determine the influence of the physicochemical properties of interstitial water, sediment geochemistry and sediment grain size on the health of mangroves in three Basins (I, II and III) in Cuyutlán Lagoon, Mexico. Monthly sampling was conducted at eight stations from February to October 2014. The optimum reforestation conditions were observed at stations in Basin I (1A and 1B) and II (2C and 2D), where exchange of water between the ocean and lagoon predominates (Tepalcates and Ventanas Channels) and tidal influence induces water exchange that generates increased dissolved oxygen (3-4 mg/l) concentrations, low salinity (20-30) and greater coverage of healthy mangrove, with sufficient organic carbon (4-6%) for assimilation by the plants. By contrast, stations in Basin III were characterised by water stagnation resulting in increased salinity (40-50), depletion of the dissolved oxygen concentrations (0.1-2 mg/l) and low organic carbon (2%) in sediments, which contributed to low dwarf mangroves with low coverage most likely in response to environmental stress. Finally, the healthiest mangrove was found in areas where the dynamics favoured the deposition of organic carbon and medium sands in the sediment, which generated greater nutrient availability for fixation and assimilation by the roots.