The death of wild vertebrates by roadkill on highways in Brazil mainly threatens endangered fauna. The aim of the present study was to report roadkill deaths of endangered felids on the PB-400 highway between the Municipalities of Cajazeiras and Monte Horebe, in the State of Paraíba, Northeast Brazil. Two individuals of Herpailurus yagouaroundi and one of Leopardus tigrinus were found, which are respectively listed as vulnerable and endangered. These results show the need for actions by the government and civil society for better management regarding the conservation of wild medium-sized felines and mitigating actions to avoid the death of wild fauna on highways.