the objective of this paper is to analyze the location pattern of occupational employment in Brazil in 2010, as well as to test of the hypothesis of functional specialization according to the size of Brazilian municipalities and if this specialization changes according to the industrial sector. For this, we used the local Moran's I and the Locational Quotient. The results show that there is significant spatial heterogeneity in the distribution of occupations in the industrial sector in Brazilian municipalities. In addition, the hypothesis of functional specialization in function of the size of the cities and the importance to analyze each sector separately was confirmed. As not all sectors present the same pattern of functional specialization, especially for occupations related to management and R&D activities. These results provide additional information to understand sectoral and occupational structure of regional economies, factors that have a direct influence in the regional growth and development.