Mental illnesses are frequent co-morbid conditions in chronic systemic diseases. High incidences of depression, anxiety and cognitive impairment complicate cardiovascular and metabolic disorders such as hypertension and diabetes mellitus. Lifestyle changes including regular exercise have been advocated to reduce blood pressure and improve glycaemic control. The purpose of this project was to evaluate the effect of physical training on the most prevalent corollary psychiatric problems in patients with chronic organic ailments. This longitudinal study assessed the mental health of hypertensive (age: 57 ± 8 years) and/or diabetic (age: 53 ± 8 years) patients using minimental state examination, Beck's depression inventory, Beck's anxiety inventory and self-reporting questionnaire-20 before and after a 3-month supervised resistance and aerobic exercise programme comprising structured physical activity three times a week. Clinically relevant improvement was observed in the Beck's depression inventory and Beck's anxiety inventory scores following the 12-week training (61%, p = 0.001, and 53%, p = 0.02, respectively). Even though statistically not significant (p = 0.398), the cognitive performance of this relatively young patient population also benefited from the programme. These results demonstrate positive effects of active lifestyle on non-psychotic mental disorders in patients with chronic systemic diseases, recommending exercise as an alternative treatment option.

Introduction: Physical training is recommended by current guidelines as a preventive measure and as a tool to supplement pharmacological therapy in the treatment of hypertension and its pathological manifestations. However, there is considerable uncertainty regarding the best training prescription for blood pressure control in patients with resistant hypertension. Objective: To evaluate the effect, over twelve weeks, of an aerobic and resistance exercise program on blood pressure, anthropometric and biochemical parameters of patients with resistant hypertension. Methods: Eleven patients with resistant hypertension were randomly divided into two groups: resistance training and aerobic training. Blood pressure was recorded by 24-hour outpatient monitoring before and after 12-week training. The Student t-test was used to compare resistance and aerobic exercise groups, while the paired t and Wilcoxon tests were used to analyze pre- and post-exercise data. The level of significance was 0.05. Results: In the group that underwent aerobic training, mean systolic, diastolic and total blood pressure readings were significantly lower over the 24 hours analyzed, dropping by 14 mmHg, 7 mmHg and 10 mmHg, respectively, and in the waking period. The resistance training group showed no significant change in blood pressure, despite the significant improvement in HDL levels. Conclusion: Twelve weeks of aerobic exercises resulted in significantly lowered blood pressure in individuals with resistant hypertension, while resistance exercises were more effective in increasing HDL. Level of evidence II, Therapeutic study.

A prevalência de diabetes mellitus está sendo considerada uma epidemia global, com 382 milhões de pessoas atualmente afetadas em todo o mundo e previsão de aumento para 592 milhões para o ano 2035. Atualmente, o Brasil é o quarto país no mundo em número de diabetes. O presente estudo teve como objetivo descrever as características epidemiológicas de indivíduos com diabetes mellitus atendidos no Centro Hiperdia da cidade de Viçosa-MG, considerando características sociodemográficos, fatores de risco modificáveis e não modificáveis. Trata-se de um estudo descritivo, quantitativo, documental e de corte transversal. Foram analisados 547 prontuários, sendo 218 inativos e 329 pacientes ativos. A análise dos pacientes ativos demonstrou que 51% do número total de pacientes apresentavam diabetes mellitus tipo 2 associada à hipertensão. Em relação aos pacientes ativos, 72% apresentavam baixa renda familiar, 74% apresentavam baixa escolaridade, 74%, 78% e 57% apresentavam hipertensão arterial, sobrepeso/obesidade, inatividade física, respectivamente. A presença de dois ou mais antecedentes familiares para doenças coronarianas e metabólicas foi encontrada em 79% dos pacientes. A análise da glicemia de jejum e pós-prandial demonstrou valores inadequados em mais de 50% dos pacientes ativos. Os pacientes com diabetes atendidos pelo Centro Hiperdia de Viçosa apresentaram tanto fatores de risco modificáveis quanto não modificáveis, sendo ambos complicadores para o controle do diabetes e de um bom estado de saúde. Palavras-chave: AbstractThe prevalence of diabetes mellitus is being considered a global epidemic, with 382 million people currently affected worldwide and increase forecast for 592 million for the year 2035. Currently, Brazil is the fourth country in the world in number of diabetes. This study aimed to describe the epidemiological characteristics of individuals with diabetes mellitus treated at Hiperdia Center of Viçosa-MG, considering socio demographic, modifiable risk factors and not modifiable. This is a descriptive study, quantitative, documentary and cross-sectional. 547 records were analyzed, 218 retirees and 329 active patients. The analysis of the active patients showed that 51% of the total number of patients had a higher prevalence of type 2 diabetes mellitus associated with hypertension. In relation to active patients, 72% had low family income, 74% had low education, 74%, 78 % and 57% had high prevalence of hypertension, overweight/obesity, physical inactivity, respectively. The presence of two or more family history of coronary and metabolic diseases was found in 79% of patients. The analysis of fasting and postprandial proved inadequate values by more than 50% of the active patients. Patients with diabetes attended by the Hiperdia Center of Viçosapresented in addition to the disease itself, modifiable and non-modifiable risk factors, both being complicating for diabetes control and a good health.

Overweight/obesity has become a worldwide epidemic, and factors such as a sedentary lifestyle and inadequate eating habits directly contribute to the development of this condition. Studies indicate that rapid weight gain at critical development stages, such as the lactation period, is associated with the development of obesity, cardiovascular diseases, and diabetes in the long term. In addition to metabolic changes during adulthood, overweight/obesity may influence reproductive function of the population. In this context, the present study aimed to evaluate postnatal overfeeding effects on male and female Wistar rat reproductive parameters. Postnatal overfeeding was induced by applying the litter reduction method for both sexes. Forty animals were used, divided into four groups: two with normal litters (NL♂ and NL♀) and two with small litters (SL♂ and SL♀). The males were euthanized at 90 days of age, on the same date the females were mated. Females were also euthanized after the 20-day gestation. Metabolic and reproductive variables were analyzed. Regarding males, SL animals showed increased body weight, adiposity, and decreased relative weight of the seminal vesicle, prostate, and epididymis as well as changes in the ITT and OGTT glycemic tests. Concerning females, SL animals presented increased body weight, relative perigonadal fat weight, glucose intolerance as well as modify the vaginal opening and increased weight of female pup. The litter reduction method was efficient in leading to metabolic and reproductive alterations in male and female Wistar rat.

Chronic disorders such as hypertension and diabetes mellitus are often associated with depressive and anxiety symptoms, as well as cognitive decline. Once developed, psychological support is essential for improving the quality of life. This study is aimed at identifying impaired mental health in connection with these systemic metabolic disorders. A total of 34 patients were included in this cross-sectional study: 17 hypertensive individuals with a mean age of 59 ± 10 years, and 17 diabetic patients aged 54 ± 10 years. The following psychometric tests were used: Mini-Mental State Examination (MMSE), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and self-reporting questionnaire (SRQ-20). A large number of patients with high blood pressure or diabetes was associated with mental health problems (82% or 65%, respectively; p = 0.246). Affective disorder, especially moderate to severe depression, was seen mainly in diabetic patients (76%), whereas hypertensive individuals had higher prevalence of anxiety (64%). There was no cognitive impairment in this middle-aged population. This study shows a high proportion of depression and anxiety symptoms in patients with hypertension or diabetes mellitus, reinforcing the importance of psychiatric support for appropriate control of these metabolic disorders.