Paracoccidioidomycosis (PbM) is an infection caused by a dimorphic fungus called Paracoccidioides brasiliensis.It occurs in Latin America, with incidence of 1 to 3 per 100,000 inhabitants in endemic areas. the digestive tract is usually not affected, but when it occurs, it may lead to events similar to colorectal neoplasm and inflammatory bowel disease (IBD). This is a case report of a 68-year-old female patient, with diarrhea without blood or mucus for 6 months, weight loss of 8 kg over the period.