Objective: We assessed the efficacy of colchicine in COVID-19 patients through a systematic review. Methods: Six databases were searched until March 2022 for studies assessing colchicine versus control in hospitalized patients with COVID-19. The primary outcome was mortality, and secondary outcome was length of hospitalization. Inverse variance and random effect meta-analyses were performed. The strength of evidence was assessed using GRADE. Results: Nine studies (five randomized clinical trials (RCTs) and four non-randomized studies of intervention (NRSI); n = 13,478). Colchicine did not reduce mortality in comparison with the standard of care in RCTs (RR 0.99; 95%CI 0.90 to 1.10; p = 0.90); however, it did reduce mortality in NRSI studies (RR 0.45; 95%CI 0.26 to 0.77; p = 0.02). In the analysis of RCTs, colchicine did not reduce the length of hospitalization in comparison with the standard of care (MD: −2.25 days; 95%CI: −9.34 to 4.84; p = 0.15). Most studies were scored as having a high risk of bias. Quality of evidence was very low for primary and secondary outcomes. Conclusion: Colchicine did not reduce the mortality and length of hospitalization in comparison with the standard of care in hospitalized patients with COVID-19. The published evidence is insufficient and of very low quality to recommend treatment in patients with COVID-19.

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Background: To determine the prevalence and associated factors of adolescent pregnancy in Peru, 2015-2019. Methods: A population-based analytical cross-sectional study was conducted using pooled data from the Demographic and Family Health Surveys of Peru 2015-2019. A total weighted sample of 6892 adolescent girls aged 15 to 19 years with a history of sexual intercourse were included. Finally, the adjusted prevalence ratio (aPR) with 95% confidence interval (CI) were reported to determine the factors that were significantly associated with adolescent pregnancy. Results: The prevalence of adolescent pregnancy in Peru was 30.1% (95%CI: 28.4–31.8%). In the multivariable analysis; being 17-19 years (aPR: 1.38; 95%CI :1.22–1.56), having a partner (aPR: 4.08; 95%CI: 3.46–4.81) and belonging to the Quechua ethnicity group (aPR: 1.20; 95%CI: 1.09–1.32), were associated with a higher prevalence. Whereas, having an occupation (aPR: 0.81; 95%CI: 0.75–0.88), currently studying (aPR: 0.42; 95%CI: 0.36–0.49), belonging to the second (aPR: 0.91; 95%CI: 0.84–0.98), third (aPR: 0.80; 95%CI: 0.72–0.89), fourth (aPR: 0.76; 95%CI: 0.64–0.89) and fifth (aPR: 0.55; 95%CI: 0.41–0.73) wealth quintile, initiating sexual relations between 17-19 years (aPR: 0.52; 95%CI: 0.46–0.59), perceiving a future pregnancy as a problem (aPR: 0.77; 95%CI: 0.70–0.83) and knowledge of the moment in the cycle when she could become pregnant (aPR: 0.84; 95%CI: 0.76–0.93), were associated with a lower prevalence of pregnancy. Conclusions: About three in 10 adolescents who initiated their sexual life presented with at least one pregnancy. Age, marital status, employment, education, wealth, ethnicity, age at first intercourse, knowledge of when in the cycle she may become pregnant, and perception of future pregnancy were associated with adolescent pregnancy. It is necessary to increase national policies on family planning and sex education among adolescents to reduce the prevalence of adolescent pregnancy in Peru.

Objective: To assess the factors associated with adequate breastfeeding (ABF) among Peruvian mothers during 2019. Materials and Methods: We performed a secondary analysis of the 2019 Demographic and Family Health Survey (ENDES) database of Peru. ABF was defined based on the recommendations of the World Health Organization, which defined it as starting breastfeeding within the first hour of life and continuing with exclusive breastfeeding for up to 6 months. To determine the factors associated with ABF, a Poisson generalized linear models with log-link function was used. Adjusted prevalence ratios (aPR) with their respective 95% confidence intervals (95% CI) were calculated. Results: A prevalence of ABF of 48.1% was identified among 11,157 women who reported at least one child in the last five years. Most of them were young (68.6%) and lived in urban areas (65.5%). Furthermore, being unemployed (aPR:1.02; 95% CI:1.00–1.04); residing on the coast, except for Metropolitan Lima (aPR:1.08; 95% CI:1.04–1.11), the highlands (aPR:1.14; 95% CI:1.11–1.18), and the jungle (aPR:1.20; 95% CI: 1.16–1.24); having had a vaginal delivery (aPR:1.30; 95% CI:1.27–1.05); and having two children (aPR:1.03; 95% CI:1.01–1.05) or three or more children (aPR:1.03; 95% CI:1.01–1.05) were associated with a higher frequency of ABF. Conclusions: One out of two women between 18–59 with children performed ABF. The factors associated with ABF were the current occupation, region of residence, type of delivery, and parity. Health policies and strategies should be implemented, considering our results, to promote maternal counseling by health personnel in order to increase the prevalence of ABF in the Peruvian population.

Metastatic infection as an infrequent complication of Staphylococcus aureus bacteremia in neonates is challenging due to the limited literature. To report the clinical case of a premature neonate who developed a metastatic infection as a complication of S. aureus bacteremia. We present the case of a premature neonate admitted to the Neonatal Intensive Care Unit, diagnosed with bacterial sepsis, neonatal respiratory distress syndrome, and involvement by premature rupture of the membrane. A patch catheter was inserted, and he was successfully treated for E. coli bacteremia. He was re-admitted for late sepsis due to infection with multi-sensitive S. aureus in a patch catheter. An abscess appears on the front of the chest due to S. aureus, confirming metastatic infection. The abscess was drained with a favorable resolution of the clinical picture. In neonates submitted to invasive procedures, it is essential to monitor the clinical evolution and early identification of metastatic infection after Staphylococcus aureus bacteremia and provide early treatment to avoid sequelae.